CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction.

Oncotarget
Jian LiXin-Yuan Guan

Abstract

Oncology immunity was reported to play a key role in cancer development and progression, so we investigated the prediction role of several immune markers in esophageal squamous cell carcinoma (ESCC) patients after operation in this study. 66 primary ESCC tumor tissues and four sets of tissue microarrays including 705 primary ESCC tumor tissues from four centers were collected and analyzed. Expressions of several immune markers in ESCC tumor tissue were detected with immunohistochemistry staining. Their distribution densities were analyzed with InForm™ 2.0.1 software. All statistic analyses were performed with SPSS16.0 and Stata version 10.0. Survival analyses assessed by Kaplan-Meier plots and log-rank tests demonstrated that densities of CD68 and interleukin 13 (IL-13) in tumor stroma were positively correlated with the overall survival of ESCC patients after operation (p < 0.01 for CD68, p < 0.001 for IL-13). Further, a model based on tumor stroma densities of CD68 and IL-13 was constructed and it could significantly classify patients with poor or good prognosis. This model could further identify high-risk group and low-risk group at the same Tumor lymph Nodes Metastases (TNM) stage. Lastly, a more accuracy model based on TNM...Continue Reading

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Citations

Oct 25, 2016·The Annals of Thoracic Surgery·Vernissia TamKatie S Nason
Aug 9, 2020·Cancer Management and Research·Peng HanFan Li

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Software Mentioned

Med
Pub
InForm
[UNK]
SPSS16
Nuance
Vectra
Stata

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