CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

Nature
Lawrence R ShiowMehrdad Matloubian

Abstract

Naive lymphocytes continually enter and exit lymphoid organs in a recirculation process that is essential for immune surveillance. During immune responses, the egress process can be shut down transiently. When this occurs locally it increases lymphocyte numbers in the responding lymphoid organ; when it occurs systemically it can lead to immunosuppression as a result of the depletion of recirculating lymphocytes. Several mediators of the innate immune system are known to cause shutdown, including interferon alpha/beta (IFN-alpha/beta) and tumour necrosis factor, but the mechanism has been unclear. Here we show that treatment with the IFN-alpha/beta inducer polyinosine polycytidylic acid (hereafter 'poly(I:C)') inhibited egress by a mechanism that was partly lymphocyte-intrinsic. The transmembrane C-type lectin CD69 was rapidly induced and CD69-/- cells were poorly retained in lymphoid tissues after treatment with poly(I:C) or infection with lymphocytic choriomeningitis virus. Lymphocyte egress requires sphingosine 1-phosphate receptor-1 (S1P1), and IFN-alpha/beta was found to inhibit lymphocyte responsiveness to S1P. By contrast, CD69-/- cells retained S1P1 function after exposure to IFN-alpha/beta. In coexpression experiments, ...Continue Reading

References

Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·M Degré
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D SanchoF Sánchez-Madrid
Mar 23, 2001·Nature Immunology·G BikahM G McHeyzer-Williams
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshinori NakayamaSteven F Ziegler
Jun 1, 2002·International Immunology·Chiguang FengPaul E Love
Dec 7, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Markus Graeler, Edward J Goetzl
May 7, 2003·The Journal of Experimental Medicine·Enric EspluguesPilar Lauzurica
Jul 29, 2003·International Immunology·Kaoru MurataToshinori Nakayama
Aug 28, 2003·Current Opinion in Chemical Biology·Hugh Rosen, Jiayu Liao
Sep 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hugh RosenMichael G McHeyzer-Williams
Sep 17, 2003·Journal of Biology·Peter ChuX Charlene Liao
Jan 21, 2004·The Journal of Biological Chemistry·Maria L AllendeRichard L Proia
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Volker BrinkmannTimothy Hla
Mar 5, 2005·Trends in Immunology·David SanchoFrancisco Sánchez-Madrid
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·David B RosenLewis L Lanier

❮ Previous
Next ❯

Citations

Apr 9, 2008·Inflammatory Bowel Diseases·Bertus EksteenDavid H Adams
Dec 14, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Constantin Bode, Markus H Gräler
Aug 16, 2011·Cellular and Molecular Life Sciences : CMLS·Ivan Dzhagalov, Hyewon Phee
Jun 15, 2010·Immunogenetics·Line M FlornesSigbjørn Fossum
Aug 21, 2013·Trends in Molecular Medicine·Roberto González-AmaroPilar Martín
Mar 19, 2008·Immunology and Cell Biology·Frederick MassonGabrielle T Belz
Apr 9, 2008·Immunology and Cell Biology·Kamal M Khanna, Leo Lefrançois
Aug 20, 2008·Immunology and Cell Biology·Gib Bogle, P Rod Dunbar
Mar 21, 2012·Immunology and Cell Biology·Kerstin KieferAnn Marshak-Rothstein
Mar 7, 2012·Immunology and Cell Biology·David F Tough
Nov 8, 2012·Mucosal Immunology·L S Cauley, L Lefrançois
May 12, 2009·Nature Genetics·Jeffrey C BarrettUNKNOWN Type 1 Diabetes Genetics Consortium
Jul 21, 2010·Nature Immunology·Andrea C Carpenter, Rémy Bosselut
Jul 9, 2011·Nature Immunology·Brian S Sheridan, Leo Lefrançois
Oct 29, 2013·Nature Immunology·Laura K MackayThomas Gebhardt
Jun 21, 2007·Nature Immunology·David W O'Neill, Nina Bhardwaj
Oct 24, 2006·Nature Immunology·Stefan WelteAlexander Steinle
May 29, 2007·Nature Immunology·Nicolas FazilleauMichael G McHeyzer-Williams
Nov 21, 2007·Nature Immunology·Susan R Schwab, Jason G Cyster
Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Sep 13, 2008·Nature Reviews. Immunology·Juan RiveraAna Olivera
Aug 1, 2009·Nature Reviews. Immunology·Scott N Mueller, Ronald N Germain
Jun 28, 2011·Nature Reviews. Immunology·Paul E Love, Avinash Bhandoola
Sep 29, 2012·Nature Reviews. Immunology·Jean-Philippe GirardReinhold Förster
Apr 20, 2013·Nature Reviews. Immunology·David Masopust, Jason M Schenkel
Jan 9, 2008·Immunology and Cell Biology·Mohammed AlsharifiMatthias Regner
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anna I ProiettoLi Wu
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Irina L GrigorovaJason G Cyster
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nu Zhang, Michael J Bevan
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kenta ShinodaToshinori Nakayama
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rachel A GottschalkJames P Allison
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bailey E FreemanMark K Slifka
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen P Schoenberger
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Judith N MandlRonald N Germain
Dec 25, 2009·The Journal of Biological Chemistry·Sven-Christian Sensken, Markus H Gräler
May 14, 2010·The Journal of Biological Chemistry·Alexander J BankovichJason G Cyster
Feb 28, 2007·The Journal of Experimental Medicine·César Nombela-ArrietaJens V Stein

❮ Previous
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