CD7 expression in acute myeloid leukemia

Leukemia & Lymphoma
G Del PoetaG Papa

Abstract

The clinical significance of the expression of CD7 antigen on the blasts of 207 consecutive patients with de novo acute myeloid leukemia (AML) was evaluated. For this purpose, fifty-three CD7+ patients (23 females and 30 males; mean age 52 years) were analyzed and classified into the following subtypes according to French-American-British (FAB) classification: 7 M0, 13 M1, 9 M2, 1 M3, 9 M4, 14 M5. Immunophenotypic studies were carried out by flow cytometry and blast cells were selected on the basis of forward light scatter gating and pan-myeloid marker, either CD13 or CD33. All the CD7+ patients were negative for surface CD3 and T-cell-receptor (TCR) molecules. We found no correlation between CD7 expression and sex, age, hepatosplenomegaly and/or central nervous system involvement. The immaturity of CD7+ leukemic cells was supported by the high expression of CD34 (P = 0.001). CD7 positivity was significantly associated with a white blood cell count (WBC) greater than 100 x 10(9)/L (P = 0.003). P-Glycoprotein (P-170) expression was also evaluated in 135 patients by a flow-cytometric assay: there was a close relationship between CD7 and P-170 positivity (P < 0.001). For remission induction, all patients received therapeutic regim...Continue Reading

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Citations

Apr 10, 2002·International Journal of Hematology·Tsuyoshi MutaYoshiyuki Niho
Aug 8, 2001·American Journal of Clinical Pathology·N J KarandikarS H Kroft
Sep 3, 2011·International Journal of Laboratory Hematology·J M KlcoJ L Frater
Oct 22, 2011·PloS One·Sanja AveicGiuseppe Basso
Jul 16, 2020·Cytometry. Part B, Clinical Cytometry·Benjamin D HedleyLiliana Tejidor
Jun 5, 2018·Hematological Oncology·Alexandra JungeThomas Pabst
Feb 23, 2020·Children·Rebecca EpperlyMireya Paulina Velasquez

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