CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion

PloS One
Rafael Correa-RochaMarjorie Pion

Abstract

In our work, we analyzed the role of the CD100/CD72 and PD-1/PD-L1 axes in immune response dysfunction in human immunodeficiency virus (HIV)-1 infection in which high expressions of PD-1 and PD-L1 were associated with an immunosuppressive state via limitation of the HIV-1-specific T-cell responses. CD100 was demonstrated to play a relevant role in immune responses in various pathological processes and may be responsible for immune dysregulation during HIV-1 infection. We investigated the function of CD72/CD100, and PD-1/PDL-1 axes on T and B cells in HIV-infected individuals and in healthy individuals. We analyzed the frequencies and fluorescence intensities of these four markers on CD4+, CD8+ T and B cells. Marker expressions were increased during active HIV-1 infection. CD100 frequency on T cells was positively associated with the expression of PD-1 and PD-L1 on T cells from HIV-infected treatment-naïve individuals. In addition, the frequency of CD72-expressing T cells was associated with interferon gamma (IFN-γ) production in HIV-infected treatment-naïve individuals. Our data suggest that the CD72/CD100 and PD-1/PD-L1 axes may jointly participate in dysregulation of immunity during HIV-1 infection and could partially explain...Continue Reading

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Citations

Nov 7, 2019·Biochemistry. Biokhimii︠a︡·E M Kuklina
Jun 30, 2019·Scientific Reports·Marta EpeldeguiOtoniel Martínez-Maza
Feb 11, 2020·Frontiers in Immunology·Frances Winkler, Bertram Bengsch
Oct 7, 2020·Nucleic Acids Research·Smitha Srinivasachar BadarinarayanDaniel Sauter
Jun 3, 2021·International Journal of Molecular Sciences·Hadia FarrukhKaren Mossman

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Methods Mentioned

BETA
ELISA
flow cytometry
Fluorescence

Software Mentioned

Kaluza Analysis

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