CD73-adenosine: a next-generation target in immuno-oncology

Immunotherapy
David AllardJohn Stagg

Abstract

Cancer immunotherapy has entered in a new era with the development of first-generation immune checkpoint inhibitors targeting the PD1/PD-L1 and CTLA-4 pathways. In this context, considerable research effort is being deployed to find the next generation of cancer immunotherapeutics. The CD73-adenosine axis constitutes one of the most promising pathways in immuno-oncology. We and others have demonstrated the immunosuppressive role of CD73-adenosine in cancer and established proof-of-concept that the targeted blockade of CD73 or adenosine receptors could effectively promote anti-tumor immunity and enhance the activity of first-generation immune checkpoint blockers. With Phase I clinical trials now underway evaluating anti-CD73 or anti-A2A therapies in cancer patients, we here discuss the fundamental, preclinical and clinical findings related to the role of the CD73-adenosinergic pathway in tumor immunity.

References

Dec 15, 1994·International Journal of Cancer. Journal International Du Cancer·D W HoskinJ Blay
Feb 13, 1997·Biochemical and Biophysical Research Communications·B A WilliamsD W Hoskin
Aug 30, 2000·Nature·C M PerouD Botstein
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jozef SpychalaBeverly S Mitchell
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shigeki TsutsuiChristopher Power
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Sep 3, 2004·The Journal of Clinical Investigation·Hayo CastropJurgen Schnermann
Dec 8, 2004·The Journal of Experimental Medicine·Linda F ThompsonSean P Colgan
Aug 30, 2005·Trends in Pharmacological Sciences·György HaskóPeter Illes
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
May 24, 2006·Melanoma Research·Rafal SadejAndrzej C Skladanowski
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J SmallRobert M Hershberg
Aug 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Akio OhtaMichail Sitkovsky
Sep 5, 2006·Cancer Research·Michael SynowitzHelmut Kettenmann
Sep 13, 2006·Molecular Cancer Research : MCR·Cho-Lea TsoStanley F Nelson
Oct 27, 2006·Nucleosides, Nucleotides & Nucleic Acids·R SadejA C Skladanowski
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Almut GrenzHolger K Eltzschig
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Eliana BignottiAlessandro D Santin
Mar 14, 2007·Circulation·Tobias EckleHolger K Eltzschig
May 16, 2007·The Journal of Experimental Medicine·Silvia DeaglioSimon C Robson
Jun 26, 2007·Clinical & Experimental Metastasis·Xiuling ZhiLianhua Yin
Jul 24, 2007·Biochimica Et Biophysica Acta·Elizandra BraganholAna M O Battastini
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shirin Khambata-FordDavid J Mauro
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca DentSteven A Narod
Aug 3, 2007·Journal of Cancer Research and Clinical Oncology·Li WangPing Zhou
Feb 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia LiedtkeLajos Pusztai
Feb 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhongsheng PengBruce N Cronstein
Mar 21, 2008·The New England Journal of Medicine·Martin G SandaJohn T Wei
Jun 11, 2008·Breast Cancer Research and Treatment·Rebecca DentSteven A Narod
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey H MillsMargaret S Bynoe
Jul 19, 2008·Molecular and Cellular Biochemistry·Luci BavarescoAna Maria Oliveira Battastini
Aug 21, 2008·Neoplasia : an International Journal for Oncology Research·Sergey RyzhovIgor Feoktistov
Oct 1, 2008·European Journal of Immunology·Jussi NiemeläLaura Airas
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·John StaggMark J Smyth

❮ Previous
Next ❯

Citations

Oct 21, 2016·Oncoimmunology·Luca AntonioliGyörgy Haskó
Feb 9, 2017·Immunology and Cell Biology·David AllardJohn Stagg
Mar 5, 2017·Immunological Reviews·Bertrand AllardJohn Stagg
Apr 13, 2017·Expert Review of Anticancer Therapy·Theresa L Whiteside
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Samaneh ArabJamshid Hadjati
Apr 13, 2018·International Journal of Molecular Sciences·Tiziana VaisittiSilvia Deaglio
Oct 24, 2017·Nature Reviews. Cancer·Dipti VijayanMark J Smyth
Dec 6, 2017·Journal of Translational Medicine·Silvana MorelloPaolo Antonio Ascierto
Jun 1, 2018·Physiological Reviews·Pier Andrea BoreaKatia Varani
Jan 24, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L BowserHolger K Eltzschig
Aug 3, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jiao Wang, Sandro Matosevic
Jan 19, 2019·Journal of Personalized Medicine·David J Hermel, Darren Sigal
Jan 30, 2019·Journal of Cellular Physiology·Anvar SoleimaniMahmoud Reza Jaafari
Dec 6, 2018·Current Stem Cell Research & Therapy·Alessandro Poggi, Maria R Zocchi
Oct 23, 2019·Frontiers in Immunology·Tiziana VaisittiSilvia Deaglio
Nov 27, 2019·The Journal of Clinical Investigation·Shi Yong NeoAndreas Lundqvist
Mar 26, 2019·Human Antibodies·Farzad KobarfardSoudeh Ghafouri-Fard
Jun 14, 2019·Expert Opinion on Therapeutic Targets·Stefania MerighiStefania Gessi
Jan 30, 2018·PLoS Computational Biology·Rahila RahimovaLaurent Chaloin
Jan 5, 2019·Cancer Immunology, Immunotherapy : CII·Amedeo SciarraLaurence de Leval
Dec 20, 2019·Virchows Archiv : an International Journal of Pathology·Bruna CerbelliGiulia d'Amati
Apr 5, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Daniel R AlmquistTanios S Bekaii-Saab
Jul 18, 2020·Virchows Archiv : an International Journal of Pathology·Kyösti TahkolaJan Böhm
Dec 27, 2016·Frontiers in Immunology·Florian Wirsdörfer, Verena Jendrossek
Jun 22, 2019·Immunotherapy·Siqi ChenBin Zhang
Sep 11, 2019·Immune Network·Samaneh Arab, Jamshid Hadjati
Oct 18, 2018·Cancer Immunology Research·Caterina BartolacciAugusto Amici
Oct 31, 2020·The Journal of Biological Chemistry·James E StefanoKatarina Radošević
Jul 11, 2020·Cell·Michael A GilletteUNKNOWN Clinical Proteomic Tumor Analysis Consortium

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
xenografts
surgical resection
PCR

Clinical Trials Mentioned

NCT02403193
NCT02503774

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.