CD8+ CD28- CD127lo CD39+ regulatory T-cell expansion: A new possible pathogenic mechanism for HIV infection?

The Journal of Allergy and Clinical Immunology
Daniela FenoglioGilberto Filaci

Abstract

HIV-associated immunodeficiency is related to loss of CD4+ T cells. This mechanism does not explain certain manifestations of HIV disease, such as immunodeficiency events in patients with greater than 500 CD4+ T cells/μL. CD8+CD28-CD127loCD39+ T cells are regulatory T (Treg) lymphocytes that are highly concentrated within the tumor microenvironment and never analyzed in the circulation of HIV-infected patients. We sought to analyze the frequency of CD8+CD28-CD127loCD39+ Treg cells in the circulation of HIV-infected patients. The frequency of circulating CD8+CD28-CD127loCD39+ Treg cells was analyzed and correlated with viral load and CD4+ T-cell counts/percentages in 93 HIV-1-infected patients subdivided as follows: naive (n = 63), elite controllers (n = 19), long-term nonprogressors (n = 7), and HIV-infected patients affected by tumor (n = 4). The same analyses were performed in HIV-negative patients with cancer (n = 53), hepatitis C virus-infected patients (n = 17), and healthy donors (n = 173). HIV-infected patients had increased circulating levels of functional CD8+CD28-CD127loCD39+ Treg cells. These cells showed antigen specificity against HIV proteins. Their frequency after antiretroviral therapy (ART) correlated with HIV ...Continue Reading

Citations

Jan 30, 2018·Cellular & Molecular Immunology·Xiaoyong ChenAndy Peng Xiang
Oct 9, 2019·Immunological Reviews·Léa FlippeCarole Guillonneau
Nov 22, 2018·Frontiers in Immunology·Gilberto FilaciAntonio Di Biagio
Jan 9, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·F KalliF Rongioletti
Jan 28, 2021·European Journal of Immunology·Veronika NiederlovaOndrej Stepanek
Apr 30, 2021·Journal of Medical Virology·Daniela FenoglioGilberto Filaci
Sep 27, 2020·Cellular Immunology·Jason R Lees

❮ Previous
Next ❯

Related Concepts

Related Feeds

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.