CD8+ CD28+ /CD8+ CD28- T cell equilibrium can predict the active stage for patients with inflammatory bowel disease

Clinics and Research in Hepatology and Gastroenterology
Shixue DaiWei-Hong Sha

Abstract

The balance of blood CD8+CD28+/CD8+CD28- T cells has been verified to be vital for patients with ulcerative colitis (UC), but their role in inflammatory bowel disease (IBD) remains unknown. This investigation aimed to evaluate the efficiency of the balance in predicting the active stage in IBD patients. Fifty-three IBD subjects, including 31 UC and 22 Crohn's disease (CD) patients, were enrolled, and their peripheral blood CD8+CD28+ and CD8+CD28- T cell levels were tested using flow cytometry. The risk factors related to prognosis were compared between UC and CD patients. A 1-year follow-up was performed for all the IBD patients, and the CD8+ T cells and their ratio were compared at the 3rd, 6th, 9th, and 12th months during follow-up. The sensitivity and specificity of the CD8+ T cell level and balance were analyzed through receiver operator characteristic (ROC) curves. The cumulative remission lasting rates (CRLRs) under the different factors were analyzed using the Kaplan-Meier method. Higher prescription rates of immunosuppressants, steroids, probiotics, and biological agents (BAs) were found in CD subjects in comparison to UC subjects (P=0.005, 0.024, 0.034, and 0.001), as was a higher active rate during follow-up (95.5% of...Continue Reading

Citations

Jan 30, 2018·Cellular & Molecular Immunology·Xiaoyong ChenAndy Peng Xiang
Mar 26, 2020·International Immunopharmacology·Yuning JiaZhong Huang
Aug 21, 2021·Acta Neuropathologica Communications·Madelyn C HouserMalú Gámez Tansey

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