PMID: 2491800Jan 1, 1989Paper

CD8+ cell-dominant alveolitis in pulmonary sarcoidosis

Chest
E YamaguchiT Nojima

Abstract

A 55-year-old woman had bilateral hilar lymphadenopathy and retinouveitis. Microscopic examination of a biopsy specimen from a mediastinal lymph node revealed noncaseating epithelioid cell granulomas. Since granulomatous diseases of infectious origin and sarcoid reaction were reasonably excluded, she was diagnosed as having pulmonary sarcoidosis. Bronchoalveolar lavage findings were atypical in that the ratio of helper T cells to suppressor T cells (CD4/8 ratio) was 0.5 in two separate examinations, despite a moderately increased proportion of lymphocytes. Immunohistochemical examination of the lymph node also showed a predominancy of suppressor T cells. The inversion of the CD4/8 ratio suggests the presence of heterogeneity in the immunoregulatory mechanism in pulmonary sarcoidosis and may have a prognostic significance.

References

Jan 1, 1986·Annals of the New York Academy of Sciences·E C LawrenceR K Wilson
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
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Citations

Feb 1, 1992·Allergy·D M KemenyB J Holmes
Sep 1, 1990·Chest·A VerstraetenJ L Ceuppens
Nov 1, 1993·The American Journal of Medicine·C AgostiniG Semenzato

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