PMID: 8947602Nov 1, 1996Paper

CD8+ cells are the main producers of IL10 and IFN gamma after superantigen stimulation

Scandinavian Journal of Immunology
I Höidén, G Möller

Abstract

Purified CD8+ T cells were recently shown to produce TH1 as well as TH2 types of cytokines upon restimulation, indicating an important role for these cells in regulation of immune responses. However, it is not known if the CD8+ cells would contribute to cytokine production in the presence of cytokine secreting CD4+ cells. In the present study the authors have investigated the proportion of cytokine-producing CD4+ and CD8+ cells in the spleen after in vitro or in vivo stimulation. They found that stimulation of spleen cells with the superantigen Staphylococcal Enterotoxin B (SEB) in the presence of IL4 promoted production of IL10 and IFN gamma predominately by CD8+ cells. In contrast, the production of IL4 was almost exclusively confined to the CD4+ subset. When priming with SEB in vivo before subsequent restimulation in vitro, a protocol previously shown to induce anergy, up to 80% of the IL10 and IFN gamma positive cell expressed the CD8 marker. Taken together, these results emphasize the important role of cytokine-producing CD8+ cells and indicate that CD4+ and CD8+ T cells may, in a given situation, produce distinct cytokines.

Citations

Nov 25, 2003·Human Immunology·Siri H OpdalTorleiv O Rognum
Jul 1, 1997·Research in Immunology·S Florquin, L Aaldering
Oct 12, 2000·Cytokine·N TangsinmankongS Haraguchi
Nov 7, 2014·PLoS Pathogens·Silvia MorettiLuigina Romani
Apr 5, 2013·PLoS Pathogens·Claudia Gonzalez-LombanaPhillip Scott
Nov 19, 2013·Seminars in Immunology·Mark S Sundrud, Catherine Trivigno
Jan 15, 2014·Autoimmunity Reviews·Mélissa Noack, Pierre Miossec
Feb 19, 2013·Journal of Immunological Methods·Ingrid Olsen, Ludvig M Sollid
Aug 27, 2013·Trends in Immunology·Kevin P Walsh, Kingston H G Mills
Jul 31, 2013·The Journal of Allergy and Clinical Immunology·Patrick M BrunnerGeorg Stingl
Jul 2, 2005·Archives of Psychiatric Nursing·Kathleen R Delaney
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lee FaulknerShiranee Sriskandan

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