CD8 chemokine receptors in chronic obstructive pulmonary disease.

Clinical and Experimental Immunology
L J C SmythD Singh

Abstract

Increased lung CD8 cells and their expression of chemokine receptors CXCR3 and CCR5 have been previously reported in chronic obstructive pulmonary disease (COPD). Alterations of CD8-CCR3 and -CCR4 expression and their ligands in COPD patients have not been fully investigated. The objective of this study was to assess in COPD patients: (i) broncho-alveolar lavage (BAL) CD8 CCR3 and CCR4 expression in COPD patients; and (ii) airway levels of the CCR3 ligands, CCL11 and CCL5. Multi-parameter flow cytometric analysis was used to assess BAL CD3 and CD8-chemokine receptor expression in COPD patients, smokers and healthy non-smokers (HNS). CCL5 and CCL11 levels were measured in BAL, and from the supernatants of lung resection explant cultures. CD8-CCR3 and -CCR5 expression (means) were increased in COPD patients (22% and 46% respectively) and smokers (20% and 45%) compared with HNS (3% and 22%); P < 0.05 for all comparisons. CD3CXCR3 expression was raised in smokers and COPD while CD8CXCR3 and CD3 and CD8 CCR4 expression was similar between groups. CD8CCR5 expression correlated to smoking pack years (r = 0.42, P = 0.01). COPD explants released more CCL5 compared with smokers (P = 0.02), while there was low level CCL11 production. CD8C...Continue Reading

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Citations

Sep 18, 2010·Risk Analysis : an Official Publication of the Society for Risk Analysis·Louis Anthony Tony Cox
Jan 31, 2017·The Journal of Investigative Dermatology·Ahmed F RezkVitali Alexeev
Jun 10, 2011·Clinical Science·Carolyn TubbyLucy Fairclough
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Sep 28, 2017·Mediators of Inflammation·Haihong GongJinming Gao
Nov 14, 2018·Molecular Biology Reports·Shao-Bin Wang, Tao Huang
Oct 11, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maya WilliamsLucy C Fairclough

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