CD8+ epidermotropic cytotoxic T-cell lymphoma with peripheral blood and central nervous system involvement

Archives of Dermatology
Camille E IntrocasoAlain Rook

Abstract

Most cutaneous T-cell lymphomas demonstrate a malignant population with a CD4(+) phenotype. In rare cases, CD8(+) phenotypes have been described based on immunostaining of skin specimens. Although some CD8(+) lymphomas have an indolent course, others, such as CD8(+) epidermotropic cytotoxic T-cell lymphomas, are typically more aggressive. To our knowledge, involvement of peripheral blood or cerebrospinal fluid with a malignant population of CD8(+) cells demonstrated by flow cytometry and T-cell receptor gene rearrangement has not been previously described. We describe a patient with a CD8(+) cutaneous T-cell lymphoma with an initially indolent course and early stage diagnosed on the basis of a skin biopsy specimen. However, when flow cytometry was performed looking specifically at CD8(+)/CD4(-) cells in the peripheral blood and cerebrospinal fluid, a malignant population of CD8(+)/CD4(-)/CD26(-)/CD7(-) cells was discovered. It is important for prognosis and treatment to be able to identify CD8(+) epidermotropic cytotoxic T-cell lymphoma and separate it from other relatively indolent CD8(+) lymphomas. Furthermore, detection of an abnormal CD8(+)/CD26(-)/CD7(-) T-cell population within the peripheral blood has important prognosti...Continue Reading

Citations

Dec 1, 2011·The American Journal of Dermatopathology·Angel Fernandez-Flores
Jan 10, 2012·Journal of the American Academy of Dermatology·Ahmad NofalEman Salah
Dec 1, 2009·Journal of the American Academy of Dermatology·Rachel H GormleyEllen J Kim
Aug 15, 2015·The American Journal of Dermatopathology·Cynthia M MagroMilos D Pavlovic

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