CD8αα intraepithelial lymphocytes arise from two main thymic precursors

Nature Immunology
Roland RuscherKristin A Hogquist

Abstract

TCRαβ(+)CD4(-)CD8α(+)CD8β(-) intestinal intraepithelial lymphocytes (CD8αα IELs) are an abundant population of thymus-derived T cells that protect the gut barrier surface. We sought to better define the thymic IEL precursor (IELp) through analysis of its maturation, localization and emigration. We defined two precursor populations among TCRβ(+)CD4(-)CD8(-) thymocytes by dependence on the kinase TAK1 and rigorous lineage-exclusion criteria. Those IELp populations included a nascent PD-1(+) population and a T-bet(+) population that accumulated with age. Both gave rise to intestinal CD8αα IELs after adoptive transfer. The PD-1(+) IELp population included more strongly self-reactive clones and was largely restricted by classical major histocompatibility complex (MHC) molecules. Those cells localized to the cortex and efficiently emigrated in a manner dependent on the receptor S1PR1. The T-bet(+) IELp population localized to the medulla, included cells restricted by non-classical MHC molecules and expressed the receptor NK1.1, the integrin CD103 and the chemokine receptor CXCR3. The two IELp populations further differed in their use of the T cell antigen receptor (TCR) α-chain variable region (Vα) and β-chain variable region (Vβ). T...Continue Reading

References

Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason PlotkinHoward T Petrie
Mar 3, 2004·Nature Immunology·Tamar E BoursalianPamela J Fink
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne Kwan, Nigel Killeen
Aug 11, 2004·The Journal of Experimental Medicine·Tomoo UenoYousuke Takahama
Aug 11, 2004·The Journal of Experimental Medicine·Ana MisslitzReinhold Förster
Jul 21, 2006·Nature·Corey M CarlsonStephen C Jameson
Sep 19, 2007·The Journal of Experimental Medicine·Jun KunisawaHiroshi Kiyono
Oct 3, 2007·The Journal of Experimental Medicine·Tom M McCaughtryKristin A Hogquist
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa J MaKimberly S Schluns
Jul 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael B DrennanDirk Elewaut
Apr 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oludare A OdumadeKristin A Hogquist
Jul 29, 2010·Lab Animal·Robin Blair-HandonShelley Hoogstraten-Miller
Oct 5, 2010·Current Gastroenterology Reports·Brian S Sheridan, Leo Lefrançois
May 25, 2011·The Journal of Experimental Medicine·Amy E MoranKristin A Hogquist
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Oct 4, 2011·Nature Biotechnology·Peng QiuSylvia K Plevritis
May 1, 2012·Nature Immunology·Leonid A PobezinskyAlfred Singer
May 23, 2012·Nature Immunology·Gretta L Stritesky, Kristin A Hogquist
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gretta L StriteskyKristin A Hogquist
Feb 11, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea J WhiteGraham Anderson
May 11, 2015·Cell·Elizabeth M SteinertDavid Masopust
Sep 13, 2015·Immunity·You Jeong LeeKristin A Hogquist
Sep 30, 2015·The Journal of Experimental Medicine·Zicheng HuLauren I R Ehrlich
Mar 12, 2016·Cell·Xiying Fan, Alexander Y Rudensky

❮ Previous
Next ❯

Citations

Apr 13, 2018·Bio-protocol·Roland Ruscher, Kristin A Hogquist
Jun 1, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WendlandWilliam W Agace
Dec 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitri I KotovMarc K Jenkins
Jan 10, 2019·Journal of the American Society of Nephrology : JASN·Mohanraj SadasivamAbdel Rahim A Hamad
Sep 12, 2017·Cellular & Molecular Immunology·Lu Bai, Hui Peng
Apr 24, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elise R BreedKristin A Hogquist
Jul 20, 2018·Scientific Reports·Lukasz WojciechLeszek Ignatowicz
Feb 14, 2020·Journal of Leukocyte Biology·Noé Rodríguez-RodríguezJosé C Crispín
Feb 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali NazmiDanyvid Olivares-Villagómez
Apr 29, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xavier Y X SngNicole L La Gruta
May 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roxanne CollinSylvie Lesage
Jul 21, 2020·The Journal of Experimental Medicine·Roland RuscherKristin A Hogquist
Jul 15, 2020·Nature Reviews. Rheumatology·Eric GraceyDirk Elewaut
Jun 28, 2017·The Journal of Experimental Medicine·Dominic P GolecTroy A Baldwin
Sep 11, 2018·The Journal of Clinical Investigation·Alessandra PetrelliFemke van Wijk
Jan 16, 2019·Nature Immunology·David L OwenMichael A Farrar
Feb 23, 2020·Science·Jong-Eun ParkSarah A Teichmann
Mar 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luc Van Kaer, Danyvid Olivares-Villagómez
Oct 10, 2018·Frontiers in Immunology·Chun Chou, Ming O Li
Jul 2, 2019·The Journal of Clinical Investigation·Franco R D'AlessioHamid Rabb
May 18, 2020·Mucosal Immunology·Maud VandereykenMahima Swamy
Nov 12, 2019·Frontiers in Immunology·Samantha J Winter, Andreas Krueger
Aug 1, 2020·Frontiers in Immunology·Vladislava Stokic-TrticaChristoph S N Klose
Apr 26, 2019·Cell Death and Differentiation·Rushika C WirasinhaStephen R Daley
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hisashi WadaIchiro Taniuchi
Jul 6, 2018·Nature Reviews. Gastroenterology & Hepatology·Lisanne LutterFemke van Wijk
May 3, 2018·Nature Reviews. Immunology·Benjamin D McDonaldAlbert Bendelac
Oct 28, 2020·The Journal of Experimental Medicine·Rushika C WirasinhaStephen R Daley
Jan 19, 2021·Developmental and Comparative Immunology·Catarina MoreiraTiphaine Monsinjon
Jan 28, 2021·European Journal of Immunology·Veronika NiederlovaOndrej Stepanek
Feb 2, 2021·European Journal of Immunology·S Thera LeeKristin A Hogquist
May 28, 2019·Current Opinion in Immunology·Nicholas A SpidaleJoonsoo Kang
Jun 3, 2020·Mucosal Immunology·Nadia S KurdEllen A Robey

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

Cytobank Premium
SPADE
Prism
Matrix2png

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.