PMID: 2496053Apr 1, 1989Paper

CD8 is involved in both class I- and class II-induced proliferation of a cytolytic T-cell clone with dual specificity for HLA-B27 and HLA-DR2 antigens

Human Immunology
P Aparicio, J A López de Castro

Abstract

A CD3+ CD4- CD8+ cytolytic T-lymphocyte (CTL) clone, CTL 47, could be induced to proliferate in the presence of exogenous interleukin 2 by either HLA-B27.1+ or HLA-DR2+ cells. B27.1-induced proliferation was strongly and equally inhibited by an anti-B27 and by an anti-CD8 monoclonal antibody (MoAb). DR2-induced proliferation was inhibited by the same anti-CD8 MoAb less efficiently and with a different time course than anti-class II blocking, only being significant when the antibody was added ab initio or very early during the assay. These results indicate that CD8 is essential for class I-induced proliferation but that it also enhances class II-induced stimulation of this CTL clone. It is proposed that the necessary role of CD8 in class I-induced proliferation is related to its interaction with the same class I molecule bound by the T-cell receptor. The accessory role in class II-induced proliferation would be due to an additive effect on the avidity of cell adhesion, resulting from interaction of CD8 with the class I antigens on the stimulator cell, or perhaps to a regulatory role of CD8 as a transducer of early signals for T-cell activation.

References

Apr 2, 1987·Nature·Z DembićH von Boehmer
Dec 1, 1987·The Journal of Experimental Medicine·S E RatnofskyS J Burakoff
Aug 1, 1982·Human Immunology·S A EllisA McMichael
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S C MeuerE L Reinherz

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Citations

Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M H HeemskerkJ H Falkenburg

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