PMID: 8948369Dec 1, 1996Paper

CD8+ lymphocyte responses to antiretroviral therapy of HIV infection

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
A CarrD A Cooper

Abstract

CD8+ T lymphocytes may mediate important host responses to human immunodeficiency virus (HIV) infection by human leukocyte antigen (HLA)-restricted cytotoxicity and production of soluble HIV suppressor factors. CD8+ lymphocytes are also important for the suppression of many latent pathogens responsible for opportunistic disease in HIV-infected patients. There has been no systematic analysis of the responses of CD8+ lymphocyte counts to antiretroviral therapy. We compared CD8+ lymphocyte responses in seven trials of nucleoside or non-nucleoside analog reverse transcriptase inhibitors and in two trials of ritonavir, a HIV protease inhibitor. Nucleoside analog and non-nucleoside analog reverse transcriptase inhibitor monotherapy resulted in no substantial changes in CD8+ counts relative to baseline or placebo. Combination nucleoside analog therapy resulted in variable peak responses (-145 to +240 cells/mm3), which remained significantly above baseline for 0 to 12 weeks. In contrast, ritonavir monotherapy caused a peak increase of 892 CD8+ cells/mm3, which remained significantly above baseline for 32 weeks. There was a significant correlation (Rs 0.61, p = 0.01) between the peak CD4+ cell and CD8+ responses to each therapy, but no ...Continue Reading

References

Mar 1, 1990·AIDS·B D Walker, F Plata
Jul 23, 1987·Nature·B D WalkerR T Schooley
Aug 11, 1994·Nature·R A Koup, D D Ho
Oct 1, 1993·Clinical Immunology and Immunopathology·A L LandayJ A Levy
Dec 7, 1995·Nature·M BaierR Kurth
Dec 7, 1995·Nature·K Matsumura

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Citations

Jan 15, 1999·La Revue de médecine interne·S Pol, H Zylberberg
Aug 1, 1997·Current Opinion in Immunology·S Emery, H C Lane
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·L V HernandezV J Dindzans
Jan 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I RatnamP J Easterbrook
Sep 7, 2006·AIDS·Luciano Delgado PlasenciaAlberto Bravo Gutierrez
May 24, 2008·The Journal of Clinical Investigation·Toshio HisatomiJoan W Miller
Nov 17, 2009·Journal of Theoretical Biology·R A SergeevI M Rouzine
Apr 25, 2000·AIDS Research and Human Retroviruses·B N PhenixA D Badley
Jun 1, 1997·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R B Stricker, B Goldberg
Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M de MartinoA Vierucci

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