PMID: 8588347Nov 1, 1995Paper

CD8+ lymphocytes in bronchoalveolar lavage and blood: in vivo indicators of lung pathology caused by maedi-visna virus

Veterinary Immunology and Immunopathology
L LujanN J Watt

Abstract

A study to determine the putative relationship between lymphocyte phenotypic alterations in bronchoalveolar lavage fluid and stage of lung pathology in maedi-visna infected sheep has been carried out. Twenty-one ewes (16 Texel and five Scottish blackface) naturally infected by maedi-visna virus and three Oxford controls were used. Animals were killed, lungs were removed, bronchoalveolar lavage was performed and pathological studies were completed. Blood samples were also obtained from 16 animals. Lymphocytes in both bronchoalveolar lavage and peripheral blood were labelled with monoclonal antibodies against the main T lymphocyte subsets (CD4, CD8, CD5 and gamma delta TCR) in order to perform flow cytometric studies. Three aspects of pathology were studied: lymphoid interstitial pneumonia, lymphoid follicular hyperplasia and smooth muscle hyperplasia. Percentages of CD4+, CD5+, gamma delta + T cells and the value for the CD4+ / CD8+ ratio in bronchoalveolar lavage of maedi-visna infected animals were significantly decreased (P < 0.05) when compared to controls, while percentages of CD8+ lymphocytes were increased in bronchoalveolar lavage of infected sheep and they were very close to being significant (P = 0.07) when compared to...Continue Reading

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Citations

Dec 1, 1996·Veterinary Immunology and Immunopathology·I BegaraN J Watt
Aug 1, 1997·Veterinary Immunology and Immunopathology·J W McBrideB I Osburn
Sep 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B SinghA de la Concha-Bermejillo
Dec 5, 1998·Journal of Comparative Pathology·R S Campbell, W F Robinson
Oct 20, 1998·The American Journal of Pathology·J L MankowskiM C Zink
Sep 14, 2019·Transboundary and Emerging Diseases·Cynthia L BaldwinJanice C Telfer
Aug 29, 2021·Viruses·Daniel Rodríguez-MartínNoemí Sevilla

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