CD8+ lymphomatoid papulosis and its differential diagnosis

American Journal of Clinical Pathology
Cynthia M MagroE David Wright

Abstract

We describe 5 cases (4 males, 14-43 years old; 1 female, 61 years old) of primary cutaneous T-cell lymphoproliferative lesions expressing a CD8/granzyme/CD30-positive phenotype. Four cases were compatible with lymphomatoid papulosis (LyP) based on the clinical course, which was recurrent asymptomatic papular nodular lesions over years responding to methotrexate; granulomatous inflammation and lack of other inflammatory cell elements were characteristic. In 1 case, an initial erroneous diagnosis was made of aggressive epidermotropic CD8+ T-cell lymphoma. The fifth case in this series was first interpreted as representing primary cutaneous anaplastic large cell lymphoma but was later recategorized as primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma owing to the extent of extracutaneous dissemination, including testicular involvement and disease progression despite chemotherapeutic intervention. Although all cases of LyP showed sharp cytoplasmic membrane staining with perinuclear Golgi accentuation with CD30, the recategorized case of aggressive epidermotropic CD8 cytotoxic T-cell lymphoma manifested only a weak cytoplasmic staining pattern. CD8 LyP defines a distinctive entity with characteristic light m...Continue Reading

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Citations

Jan 15, 2016·Pediatric Dermatology·Mary M BarrettGlynis A Scott
Oct 11, 2011·Journal of the American Academy of Dermatology·Aieska de SouzaLawrence E Gibson
Jul 7, 2009·Journal of the American Academy of Dermatology·Aieska de SouzaRokea A el-Azhary
Jun 10, 2008·Journal of Cutaneous Pathology·Stephen P SloneDamian A Laber
Jul 11, 2008·American Journal of Hematology·Srivalli GopaluniBernard J Poiesz
Dec 3, 2013·Clinical and Experimental Dermatology·P PratsouR A Carr
Mar 29, 2014·Proteomics. Clinical Applications·Lars T Joeckel, Phillip I Bird
Oct 15, 2013·Journal of Cutaneous Pathology·Elizabeth McQuittyCarlos Torres-Cabala
Oct 21, 2016·Journal of Cutaneous Pathology·Márta MarschalkóÁgota Szepesi

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