CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection.

Virology
Megan J WelchMichael B A Oldstone

Abstract

DNAM-1 gene-deficient (-/-) mice take significantly longer to clear an acute and persistent LCMV infection in vivo than DNAM-1 +/+ mice. During acute LCMV priming, at the single cell level, DNAM-1 -/- mice made significantly less cytoplasmic CD8 TNF-α and IL-2 but not IFN-γ than their DNAM-1 +/+ counterparts. Restimulated immune memory CD8 T cells from DNAM-1 -/- and DNAM-1 +/+ mice were equivalent in cytolytic activity against LCMV-infected target cells but DNAM-1 -/- CD8 T cells had significant reductions in TNF-α and IL-2 that were associated on adoptive transfer with the inability to terminate the persistent viral infection.

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Citations

Dec 18, 2013·Immunology and Cell Biology·Lucas Ferrari de AndradeLudovic Martinet
Feb 26, 2014·Current Opinion in Gastroenterology·Eva K K HenriksenTom H Karlsen
Sep 9, 2015·Frontiers in Immunology·Isabelle Le MercierRandolph J Noelle
Mar 7, 2015·Nature Reviews. Immunology·Ludovic Martinet, Mark J Smyth
Jan 12, 2017·Cell Communication and Signaling : CCS·Kemal CatakovicRoland Geisberger
Oct 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benedetta PignoloniCristina Cerboni
May 29, 2015·Clinical and Vaccine Immunology : CVI·Bing WuBin Wang
Mar 20, 2019·European Journal of Immunology·Rosa MolfettaRossella Paolini
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelly M RamsbottomJane Oliaro
Dec 11, 2020·The Cancer Journal·Edward B Garon, Debory Yi Li
Jul 25, 2014·Annals of the Rheumatic Diseases·T H C M ReinardsM W Schilham

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