PMID: 11932195Apr 5, 2002Paper

CD8(+) T-cell homeostasis after infection: setting the 'curve'

Microbes and Infection
Vladimir P Badovinac, John T Harty

Abstract

Antigen (Ag)-specific CD8(+) T-cell responses exhibit remarkably similar kinetics after different types of infection. Starting from levels that are virtually undetectable in vivo, pathogen-specific naïve CD8(+) T cells are precisely regulated to go through rapid expansion and contraction (death) phases, achieving memory levels of Ag-specific CD8(+) T cells that are maintained for the life of the host. However, the exact mechanisms used to achieve appropriate and reproducible CD8(+) T-cell homeostasis in response to diverse pathogens remain to be determined. The possibility that early events after infection regulate major features of Ag-specific CD8(+) T-cell homeostasis will be discussed here.

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Citations

Oct 6, 2007·Immunologic Research·Aaruni KhanolkarJohn T Harty
Apr 6, 2004·Journal of Theoretical Biology·Martin J AllanAndrew Yates
Aug 24, 2005·Nature Immunology·Paul Klenerman, Ann Hill
Oct 26, 2005·Cell Research·Nu ZhangYou Wen He
Jun 24, 2003·Current Opinion in Rheumatology·Geneviève de Saint Basile, Alain Fischer
Mar 21, 2013·Critical Reviews in Immunology·Stephanie A CondottaThomas S Griffith
Jul 11, 2006·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo
Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Melanie WieselAnnette Oxenius
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Jul 11, 2006·Immunological Reviews·Vladimir P Badovinac, John T Harty
Apr 29, 2011·BMB Reports·Hyun-Tak JinSang-Jun Ha
Sep 4, 2015·Viral Immunology·Dimpu GogoiJagadish Mahanta
Jul 25, 2006·Immunity·Jodie S HaringJohn T Harty
Apr 14, 2010·BMC Biology·Amy S McKeePhilippa Marrack
Nov 9, 2004·Advances in Virus Research·J Lindsay WhittonJason K Whitmire
Apr 13, 2010·Expert Review of Clinical Immunology·Sumit Gupta, Sheila Weitzman
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Sep 12, 2006·Médecine sciences : M/S·Gaël MénaschéGeneviève de Saint Basile
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Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kelly A N MessinghamJohn T Harty
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali JabbariJohn T Harty
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie A CondottaVladimir P Badovinac
Aug 23, 2018·Frontiers in Immunology·Felix M BehrKlaas P J M van Gisbergen

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