CD8+ T cells are involved in early inflammation before macrophages in a rat adipose tissue engineering chamber model

Journal of Tissue Engineering and Regenerative Medicine
Yi YuanChuanbo Feng

Abstract

Adipose tissues regenerated using tissue engineering chambers (TECs) show the potential for applications in reconstruction of soft tissue defects. Previous studies have shown that early inflammation plays a key role in angiogenesis and adipogenesis required for adipose tissue generation. However, the sequence of events of the early inflammatory cascade is unclear. In this study, we investigated the role of early inflammatory cells in adipose tissue engineering using a rat TEC model. Rats in the TEC model were divided into five groups: the control group, the zymosan A-treated group, the 5-AIQ-treated group, the imatinib-treated group, and the CD8+ T cell injection group. Fat pad volume, angiogenesis, adipogenesis, inflammatory factor levels, and inflammatory cell infiltration in chambers after implantation were evaluated at different time points. The volume of fat pads of was higher in the zymosan A-treated and CD8+ T cell injection groups than other groups, and these two groups also showed higher levels of proinflammatory factors, greater numbers of CD31+ cells and perillipin+/Ki67+ cells, and higher macrophage infiltration. The infiltration of CD8+ T cell peaked at 3 days after implantation, which was earlier than that of macr...Continue Reading

References

Jan 10, 2012·Trends in Immunology·Yufang ShiGuangwen Ren
Jun 22, 2013·Experimental Biology and Medicine·Anita HartogJohan Garssen
Jul 13, 2013·Tissue Engineering. Part a·Heidi DebelsKeren Abberton
Jan 23, 2015·BioMed Research International·Hung-Chen WangJason Cheng-Hsuan Chiang
Apr 8, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Weiqing ZhanFeng Lu
Feb 20, 2016·Plastic and Reconstructive Surgery. Global Open·Yi YuanRei Ogawa

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Citations

Aug 28, 2020·Journal of Applied Physiology·Alexander T SougiannisE Angela Murphy
Jun 8, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Jun 16, 2021·The Journal of Clinical Endocrinology and Metabolism·Kirsten I M LoomanJessica C Kiefte-de Jong

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