CD8(+) T cells control corneal disease following ocular infection with herpes simplex virus type 1

The Journal of General Virology
Patrick M StuartDavid A Leib

Abstract

The role that T cell subsets play in herpetic stromal keratitis (HSK) has been the subject of intense research efforts. While most studies implicate CD4(+) T cells as the principal cell type mediating primary corneal disease, recent reports using knockout mice have suggested that both CD4(+) and CD8(+) T cell subsets may play integral roles in modulating the disease. Furthermore, recent studies suggest that CD8(+) T cells are directly involved in maintaining virus latency in infected trigeminal ganglia. This work has addressed these discrepancies by infecting the corneas of mice lacking CD4(+) and CD8(+) T cells with herpes simplex virus type 1 (HSV-1) and monitoring both corneal disease and latent infection of trigeminal ganglia. Results indicated that mice lacking CD8(+) T cells had more severe corneal disease than either BALB/c or B6 parental strains. In contrast, mice lacking CD4(+) T cells had a milder disease than parental strains. When mice were evaluated for persistence of infectious virus, only transient differences were observed in periocular tissue and corneas. No significant differences were found in persistence of virus in trigeminal ganglia or virus reactivation from explanted ganglia. These data support the follo...Continue Reading

References

Dec 1, 1979·Infection and Immunity·J F MetcalfR W Reichert
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P YouinouC Ferec
Jul 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·A CohenE W Gelfand
Jan 1, 1997·Immunologic Research·J Thomas, B T Rouse
Mar 9, 2000·Transplantation·Z HaskovaP M Stuart
Mar 24, 2000·The British Journal of Ophthalmology·H GhiasiS L Wechsler
Jun 3, 2000·Annual Review of Immunology·E M Shevach
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·H JiangL Chess
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A Piccirillo, E M Shevach
Nov 28, 2001·Immunological Reviews·E H FieldQ Gao
Mar 20, 2002·The Journal of Experimental Medicine·Michel Gilliet, Yong-Jun Liu
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas A FergusonDouglas R Green
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veena TanejaChella S David
Oct 24, 2002·Human Immunology·Raffaello CortesiniNicole Suciu-Foca Cortesini
Dec 14, 2002·Human Immunology·Michel Gilliet, Yong-Jun Liu
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Patrick M StuartThomas A Ferguson
May 20, 2003·Immunological Reviews·Thomas A FergusonThomas S Griffith
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julius C R HafallaFidel Zavala
Jul 10, 2003·Autoimmunity Reviews·Gilberto Filaci, Nicole Suciu-Foca
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takahiko NakamuraJoan Stein-Streilein
Sep 17, 2003·The Journal of Experimental Medicine·Susmit SuvasBarry T Rouse

❮ Previous
Next ❯

Citations

Apr 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Daniel J J CarrJohn Ash
Jan 24, 2013·Investigative Ophthalmology & Visual Science·Gilbert G JoseCurtis R Brandt
Feb 9, 2013·BMC Neuroscience·Márcia Carvalho VilelaAntonio Lucio Teixeira
May 18, 2012·Clinical & Developmental Immunology·Patrick M Stuart, Tammie L Keadle
Aug 15, 2013·Journal of Neurovirology·Kevin P EganStephen R Jennings
Mar 13, 2014·International Journal of Nanomedicine·Juan Sebastián PappalardoVladimir P Torchilin
May 23, 2014·Immunologic Research·Sushmita SinhaNitin J Karandikar
Oct 28, 2015·Journal of Immunology Research·Xiao-Tang YinPatrick M Stuart
Sep 1, 2016·Immunology and Cell Biology·Hem R GurungDaniel J J Carr
Mar 11, 2016·Journal of Virology·Kevin R MottHomayon Ghiasi
Dec 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica E MorrisPatrick M Stuart
Jan 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Devin M WestPatrick M Stuart
Jun 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher D ConradyDaniel J J Carr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.