CD8+ T cells mediate antibody-independent platelet clearance in mice.

Blood
Connie M ArthurSean R Stowell

Abstract

Platelet transfusion provides an important therapeutic intervention in the treatment and prevention of bleeding. However, some patients rapidly clear transfused platelets, preventing the desired therapeutic outcome. Although platelet clearance can occur through a variety of mechanisms, immune-mediated platelet removal often plays a significant role. Numerous studies demonstrate that anti-platelet alloantibodies can induce significant platelet clearance following transfusion. In fact, for nearly 50 years, anti-platelet alloantibodies were considered to be the sole mediator of immune-mediated platelet clearance in platelet-refractory individuals. Although nonimmune mechanisms of platelet clearance can often explain platelet removal in the absence of anti-platelet alloantibodies, many patients experience platelet clearance following transfusion in the absence of a clear mechanism. These results suggest that other processes of antibody-independent platelet clearance may occur. Our studies demonstrate that CD8(+)T cells possess the unique ability to induce platelet clearance in the complete absence of anti-platelet alloantibodies. These results suggest a previously unrecognized form of immune-mediated platelet clearance with signifi...Continue Reading

References

Apr 12, 1973·The New England Journal of Medicine·R A YankeeE S Henderson
Jan 7, 1998·The New England Journal of Medicine·UNKNOWN Trial to Reduce Alloimmunization to Platelets Study Group
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·C DenisD D Wagner
Oct 17, 2002·Cellular Immunology·Kate E HalamayDianne B McKay
Apr 14, 2005·Genesis : the Journal of Genetics and Development·Massimo DominiciDerek A Persons
Aug 7, 2007·Lancet·David F Stroncek, Paolo Rebulla
Jan 26, 2008·Seminars in Hematology·Robert McMillan

❮ Previous
Next ❯

Citations

Sep 2, 2016·Proteomics·Nourine A KamiliSean R Stowell
May 26, 2017·PLoS Pathogens·Monique Ramos de Oliveira TrugilhoJonas Perales
Apr 5, 2017·Blood·Harold C SullivanSean R Stowell
Mar 3, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Connie M ArthurSean R Stowell
Apr 9, 2016·Blood·John P Manis, Leslie E Silberstein
May 16, 2018·Frontiers in Medicine·Eugenio D HottzPatrícia T Bozza
Aug 22, 2017·Frontiers in Immunology·Prabitha NatarajanJeanne E Hendrickson
Nov 11, 2018·Blood Advances·Cheryl L MaierSean R Stowell
Aug 24, 2019·Journal of Thrombosis and Haemostasis : JTH·Shuting JiChunyan Gao
Jan 22, 2021·Blood·Rick Kapur
Jul 28, 2021·Transfusion Medicine Reviews·Kiran EjazHarold C Sullivan
Sep 19, 2021·Cancer Research·Biying WuYunlong Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved