PMID: 15375577Sep 18, 2004Paper

CD82, and CD63 in thyroid cancer

International Journal of Molecular Medicine
Zhouxun ChenCuong Hoang-Vu

Abstract

CD82 (KAI1) and CD63 (ME491) are highly glycosylated proteins which belong to the transmembrane 4 superfamily (TM4SF). CD82 has been implicated as a possible prostate cancer metastasis suppressor gene, whereas CD63 is involved in the progression of human melanoma cancer. Down-regulation of both CD82 and CD63 expression has been associated with the metastatic potential of several solid tumors. Currently, information is lacking on the role of CD82 and CD63 during thyroid carcinogenesis. The aim of this study was to determine whether the expression of CD82 and CD63 is a useful prognostic indicator in patients with thyroid carcinoma. The expression of CD82 and CD63 was analysed by reverse transcriptase-PCR (RT-PCR) and immunohistochemistry in benign goiter (n=12) and 75 primary thyroid carcinoma tissue specimens (PTC: 33, FTC: 24, UTC: 18) out of which 36 were non-metastasized primary tumors and 39 were metastasized tumors (regional lymph node and/or distant metastases). All of the benign goiter tissues showed CD82 expression. By contrast, a significant decrease in CD82 mRNA and protein levels was detected in carcinoma tissues as compared to benign goiter tissues (p<0.001). A similar down-regulation was observed in metastasized tum...Continue Reading

Citations

Feb 21, 2014·Pathology, Research and Practice·Hyeong Ju KwonKyung Chul Moon
Dec 21, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Molly Kulesz-MartinJodi Johnson
Jan 12, 2010·Oral Oncology·Marcilei Eliza Cavicchioli BuimFernando Augusto Soares
Oct 13, 2010·The Journal of Pathology·Hanna M Romanska, Fedor Berditchevski
Nov 2, 2005·Cancer Letters·Wei M Liu, Xin A Zhang
Mar 14, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mi Seon KwonYeun-Jun Chung
Aug 13, 2011·Thyroid Research·Bogusz TrojanowiczCuong Hoang-Vu
Dec 20, 2013·Cancers·Carolina SoekmadjiColleen C Nelson

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