CD9 immunohistochemical staining of breast carcinoma: unlikely to provide useful prognostic information for routine use

Histopathology
F JamilS Shousha

Abstract

CD9, a cell membrane glycoprotein, is found in a variety of tumour cells and is believed to regulate cell motility and possibly cell growth. It has been reported that the absence of CD9 is associated with increased aggressiveness of breast carcinoma, but no detailed studies of the distribution of CD9 in normal and abnormal breast tissue are available. This investigation was aimed at studying the distribution of CD9 in a wide variety of breast biopsies including normal, benign, and malignant cases, and assessing its usefulness as a prognostic marker in breast cancer. Sections of 113 breast biopsies from female and male patients including 10 normal, 23 benign, and 80 malignant cases were examined. The monoclonal antibody CD9 (Novacastra Ltd, Newcastle-upon-Tyne, UK) was used with the avidin-biotin complex immunoperoxidase technique. The results were assessed semiquantitatively using a four scale system of 3+, 2+, 1+ and negative. All normal and benign epithelial cells were strongly stained (3+). In female breast carcinomas, 40% were 3+, 49% were 2+, and 11% were 1+. Both cases of male breast carcinomas scored 3+. For female breast cancers, the results were then correlated to tumour grade, the presence or absence of lymph node met...Continue Reading

Citations

Nov 7, 2012·Oncology Reports·Vishwa Jeet AmatyaKouki Inai
Oct 13, 2010·The Journal of Pathology·Hanna M Romanska, Fedor Berditchevski
Oct 4, 2005·Biochemical and Biophysical Research Communications·Valerii ZvierievMario Chevrette
Aug 12, 2014·Molecular Cancer Research : MCR·Germana RappaAurelio Lorico
Feb 20, 2021·Experimental Biology and Medicine·Aurelio LoricoGiuseppe Pizzorno

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