journal cover

CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses

Nature Immunology

Jan 29, 2002

Janice M MoserAron E Lukacher

Abstract

CD8(+) T lymphocytes mediate immunosurveillance against persistent virus infections and virus-induced neoplasia. Polyoma virus, a highly oncogenic natural mouse DNA virus, establishes persistent infection, but only a few mice are highly susceptible to tumors induced by the virus. Mature...read more

Mentioned in this Paper

Tumor Virus Infections
Killer Cell Lectin-Like Receptor Subfamily C, Member 3
Mice, Inbred CBA
T-Lymphocyte
Klrd1 protein, mouse
Leukocyte Differentiation Antigens, Human
Suppressor T-Lymphocytes, CD8-Positive
Neoplasms
CD94 Antigen
KLRD1 wt Allele
47
1
Paper Details
References
  • References33
  • Citations98
1234
  • References33
  • Citations98
12345...

Similar Papers Found In These Feeds

NK cell Signaling

Natural killer (NK) cells are cytotoxic cells of the innate immune system that respond to foreign or host cells displaying stress signals. NK cell activity is controlled by engagement of various cell surface receptors that induce activation or inhibitory pathways, the balance of which determines the cell’s phenotype. Find the latest research on NK cell signaling here.

NK Cells: Viral Immunity

Natural Killer (NK) cells are critical for the containment of viral replication, particularly during early infection. Some viruses such as HIV and influenza have developed mechanisms to evade NK detection and infect the host. Here is the latest research on NK cells and viral immunity.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Immunologic Surveillance

Immunological surveillance occurs when T-cells detect and destroy virally infected or neoplastically transformed cells in the body. Discover the latest research on immunologic surveillance here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

NK Cells

NK cells identify and attack target cells based on integration of signals from activation and inhibitory receptors, whose ligands exhibit complex expression and/or binding patterns. Here is the latest research.


T cells: Costimulatory Receptors

T cell activation requires engagement of both the T cell receptor and a co-stimulatory molecule. Lack of a co-stimulatory signal can result in T cell anergy, deletion, or immune tolerance. Find the latest research on T cell co-stimulatory receptors here.

Oncoviral Profiles

Viral infections have been found to be responsible for causing some cancer types in humans. The collection of the viral genome gathered from cancer genome sequencing data can help identify the origin of the cancer. Here is the latest research on oncoviral profiles.

© 2020 Meta ULC. All rights reserved

CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses

Nature Immunology

Jan 29, 2002

Janice M MoserAron E Lukacher

PMID: 11812997

DOI: 10.1038/ni757

Abstract

CD8(+) T lymphocytes mediate immunosurveillance against persistent virus infections and virus-induced neoplasia. Polyoma virus, a highly oncogenic natural mouse DNA virus, establishes persistent infection, but only a few mice are highly susceptible to tumors induced by the virus. Mature...read more

Mentioned in this Paper

Tumor Virus Infections
Killer Cell Lectin-Like Receptor Subfamily C, Member 3
Mice, Inbred CBA
T-Lymphocyte
Klrd1 protein, mouse
Leukocyte Differentiation Antigens, Human
Suppressor T-Lymphocytes, CD8-Positive
Neoplasms
CD94 Antigen
KLRD1 wt Allele
47
1

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References33
  • Citations98
1234
  • References33
  • Citations98
12345...
/papers/cd94-nkg2a-receptors-regulate-antiviral-cd8-t/11812997