CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BALB/c mice

Diabetologia
A SignoreG Ruberti

Abstract

The non-obese diabetic (NOD) mouse is widely used to study the pathogenesis of insulin-dependent diabetes mellitus. However, the mechanisms responsible for beta-cell destruction, in this model, are still poorly defined. The CD95/CD95L system among other effector systems has been implicated in beta-cell death. In this study we investigated in NOD, non-obese resistant (NOR) and Balb/c mice the expression of CD95 and CD95L in alpha and beta pancreatic cells by immunohistochemistry and immunofluorescence. We demonstrate that alpha cells in the islets of Langherans constitutively express CD95L forming a natural shield around beta cells.

Citations

Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·P Murzenok, V Goranov
Dec 18, 2003·Annals of the New York Academy of Sciences·Diego G SilvaNikolai Petrovsky
Dec 18, 2003·Annals of the New York Academy of Sciences·Shiva Reddy, Jacqueline M Ross
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May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diego G SilvaBrett Charlton
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Feb 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sylvie DurantFrançoise Homo-Delarche

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