CD95L mediates tumor counterattack in vitro but induces neutrophil-independent tumor rejection in vivo

International Journal of Cancer. Journal International Du Cancer
F H IgneyP H Krammer

Abstract

Many tumors express CD95L (CD178, FasL, APO-1L) and may thus kill tumor-infiltrating lymphocytes, a phenomenon called tumor counterattack. However, presently it is not clear whether tumor counterattack is a relevant immune escape mechanism. To characterize the effect of CD95L expression of tumor cells on tumor-specific T cells, we established an in vitro system with TCR tg T cells and a model tumor antigen. Preactivated antitumor T cells were able to kill CD95L(-) and CD95L(+) tumor cells. CD95L(+) tumor cells killed activated T cells in vitro and inhibited the expansion of cytotoxic antitumor T cells in mixed lymphocyte tumor reactions. In vivo CD95L expression led to delayed tumor growth or complete tumor rejection. Neutrophils were not responsible for the delayed growth of the CD95L(+) tumors tested. In mice with neutrophils deficient for important cytotoxicity mechanisms (p47phox(-/-) or iNOS(-/-) mice), CD95L(+) tumors grew similarly as in wild-type mice. Incidence and growth rate of CD95L(+) tumors in mice injected with a neutrophil-depleting or an isotype control antibody was the same. In CD95-deficient lpr mice, tumor growth was not altered as compared to wild-type mice. Taken together, CD95L mediated tumor counterattac...Continue Reading

References

Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G J HämmerlingU Hämmerling
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·V E LaubachP A Sherman
Mar 1, 1994·The Journal of Experimental Medicine·T Suda, S Nagata
Feb 2, 1995·Nature·J DheinP H Krammer
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·L P SeungH Schreiber
Sep 1, 1995·The Journal of Experimental Medicine·S H JacksonS M Holland
Jun 1, 1993·International Immunology·C KlasP H Krammer
Feb 22, 1996·Nature·H YagitaK Okumura
Feb 1, 1997·Nature Medicine·K SeinoH Yagita
Sep 1, 1996·The Journal of Experimental Medicine·J O'ConnellF Shanahan
Aug 1, 1997·Nature Medicine·H AraiG J Nabel
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·H AraiG J Nabel
Dec 31, 1997·Science·S M KangH M Blau
Apr 29, 1998·European Journal of Immunology·S M Mariani, P H Krammer
Sep 9, 1998·The Journal of Experimental Medicine·Y GaoT A Ferguson
Oct 31, 1998·Current Opinion in Immunology·P R WalkerP Y Dietrich
Mar 31, 2000·European Journal of Immunology·F H IgneyP H Krammer
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·V Witko-SarsatL Halbwachs-Mecarelli
Oct 26, 2000·Nature·P H Krammer
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C K BehrensP H Krammer
Mar 7, 2001·Nature Medicine·N P Restifo
Mar 7, 2001·Nature Medicine·J O'ConnellF Shanahan
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M HohlbaumA Marshak-Rothstein
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuji TadaMasatoshi Tagawa
Oct 26, 2002·Cancer Cell·Anna Katharina SimonGavin R Screaton
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Ling ChenBei-Chang Yang
Sep 30, 2003·European Journal of Immunology·Frederik H IgneyPeter H Krammer

❮ Previous
Next ❯

Citations

May 13, 2005·Cancer Immunology, Immunotherapy : CII·Frederik H Igney, Peter H Krammer
Jan 26, 2006·Cancer Immunology, Immunotherapy : CII·Kerstin LangKurt S Zaenker
Jun 16, 2007·Cancer Immunology, Immunotherapy : CII·Diego O CrociO Graciela Scharovsky
Sep 26, 2012·Seminars in Immunopathology·Sven BrandauStephan Lang
May 1, 2007·Expert Opinion on Therapeutic Targets·Konstantinos Drosopoulos, Alexander Pintzas
Apr 14, 2012·Biochimica Et Biophysica Acta·Frederik J H HoogwaterOnno Kranenburg
Feb 13, 2007·European Journal of Immunology·Anna Katharina SimonAwen Gallimore
Oct 23, 2016·International Journal of Cancer. Journal International Du Cancer·Guillaume SarrabayrouseAnne Françoise Tilkin-Mariame
Nov 20, 2016·The FEBS Journal·Daniela SiegmundHarald Wajant
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fredrik ErikssonPavel Pisa
May 19, 2007·Cancer Research·Barbara FingletonLynn M Matrisian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.