CD98 expression is decreased in papillary carcinoma of the thyroid and Hashimoto's thyroiditis

Histopathology
Catriona E AndersonDonald M Salter

Abstract

CD98 is a component of the large neutral amino acid transporter (LAT), which is a cell surface amino acid transporter. CD98 also binds to and activates beta(1)-integrin, promoting anchorage-independent growth. CD98 expression is increased in a variety of carcinomas but its distribution in the normal and neoplastic thyroid gland has not been reported. The aim was to examine the immunohistochemical expression of CD98 in normal and diseased thyroid tissue. One hundred and forty thyroid cases were selected from the archives of the Department of Pathology, including normal controls, neoplasms (follicular adenoma, follicular carcinoma and papillary carcinoma) and non-neoplastic conditions (multinodular goitre, Graves' disease and Hashimoto's thyroiditis). Immunohistochemistry for CD98 was performed and each case was scored for proportion of cells and intensity of immunoreactivity. In normal thyroid, there was moderately strong expression of CD98 in the lateral cell membranes of follicular cells. A similar pattern of expression was seen in follicular adenoma, minimally invasive follicular carcinoma, multinodular goitre and Graves' disease. In most cases of papillary carcinoma and in the inflamed areas of Hashimoto's thyroiditis, expre...Continue Reading

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Citations

Nov 13, 2014·Current Opinion in Oncology·Salem I Noureldine, Ralph P Tufano
Feb 3, 2012·ANZ Journal of Surgery·Marc A SeifmanJonathan W Serpell
Dec 5, 2013·ANZ Journal of Surgery·Sze Ling WongJonathan W Serpell
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Bojana JankovicJerome M Hershman
Dec 3, 2010·Current Opinion in Rheumatology

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