Abstract
To evaluate the expression of CD99/MIC-2 surface protein in invasive breast carcinomas and demonstrate whether or not there is a relationship with tumour phenotype. Thirty-five invasive breast carcinomas, including five metaplastic carcinomas, were stained with CD99 primary antibodies using standard protocols based on streptavidin-biotin-peroxidase method. Four out of five metaplastic carcinomas expressed CD99/MIC-2 protein, three of them were matrix-producing carcinomas. From the other 30 cases, only an invasive apocrine carcinoma was positive. There was no statistical correlation between CD99 expression and the parameters analysed (histological typing and grading, proliferative index and nodal status). CD99/MIC-2 is expressed in breast carcinomas, especially in the matrix-producing variant of metaplastic carcinomas, which impairs its use as a marker to differentiate metaplastic carcinomas from primary and metastatic sarcomas of the breast. It seems to have no prognostic implications. However, phenotype similarities with other chondromyxoid tumours that also express the protein, like mesenchymal chondrosarcomas, suggest a relationship between MIC-2 reactivity and morphological differentiation.
References
Apr 1, 1991·Cancer·I M AmbrosM Salzer-Kuntschik
Jul 1, 1989·Human Pathology·E S Wargotz, H J Norris
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·F C SchmittM Lacerda
Aug 4, 1994·The New England Journal of Medicine·O DelattreT J Triche
Dec 1, 1996·Human Pathology·S R GranterA E Rosenberg
May 1, 1997·The American Journal of Surgical Pathology·M RishiF A Tavassoli
Dec 31, 1997·Human Pathology·M J CostaL M Roth
Jun 4, 1998·Journal of Surgical Oncology·H FunahashiK Katoh
Aug 26, 1998·Human Pathology·X Matias-GuiuJ Prat
Feb 4, 1999·Annals of Diagnostic Pathology·C Fisher
Jun 22, 1999·Human Pathology·R J BakerT A Longacre
Jul 8, 1999·Virchows Archiv : an International Journal of Pathology·R Lázaro-SantanderJ M Vera-Roman
Oct 19, 2000·Virchows Archiv : an International Journal of Pathology·G PelosiG Viale
Citations
Aug 7, 2012·Annals of Hematology·Junshik HongJae Hoon Lee
Oct 22, 2008·Endocrine Pathology·Mina Jamali, Runjan Chetty
Jul 16, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimihide KusafukaToru Kameya
Jul 6, 2007·Pathology International·Gen TamuraTadashi Hasegawa
Mar 15, 2013·Genes & Cancer·Ho Jun SeolJames T Rutka
Jan 31, 2004·American Journal of Clinical Pathology·Simon BergmanJacqueline K Trupiano
Mar 26, 2011·Pathology Research International·Tibor TotLeif Bergkvist
Feb 26, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Atsuko HadanoTetsuya Mine
Mar 18, 2009·American Journal of Clinical Pathology·Daniel BuxtonJun Wang
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Giuseppe PelosiGiuseppe Viale
Jul 31, 2007·Pathology, Research and Practice·Kuniyuki OkaYasushi Yatabe
Oct 8, 2004·Histopathology·A GotoM Fukayama
Mar 27, 2009·Journal of Cutaneous Pathology·A PattonR King
Feb 28, 2003·Histopathology·J A Walker, P J Carder
Jun 20, 2007·Journal of Cutaneous Pathology·Mark S KingKim M Hiatt
Oct 10, 2006·Journal of Cutaneous Pathology·Anne E WilkersonKim M Hiatt
Mar 7, 2012·International Journal of Cancer. Journal International Du Cancer·Karolina EdlundPatrick Micke
Mar 26, 2009·Reproductive Sciences·M Ruhul QuddusW Dwayne Lawrence
Jan 7, 2018·Journal of Cell Communication and Signaling·Michela PaselloKatia Scotlandi
Mar 14, 2018·Genes·Maria Cristina ManaraKatia Scotlandi
Feb 9, 2005·British Journal of Cancer·A M Hanby
Sep 21, 2006·The Journal of Biological Chemistry·Hee-Jung ByunHansoo Lee
May 7, 2014·Journal of Neuro-oncology·Ursula ÚriasSueli M Oba-Shinjo
Jul 19, 2012·Oncology Letters·Suebwong ChuthapisithTamnit Angsusinha
Oct 5, 2018·Human Antibodies·Krishna Priya ThangaretnamThangarajan Rajkumar
Oct 22, 2014·Clinics and Practice·Sawsen MeddebMohamed Tahar Yacoubi