Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent

Journal of Structural Biology
Masatoshi Esaki, Teru Ogura

Abstract

Cdc48p/p97 is a cytosolic essential AAA chaperone, which regulates multiple cellular reactions in a ubiquitin-dependent manner. We have recently shown that Cdc48p exhibits positively cooperative ATPase activity and loss of the positive cooperativity results in yeast cell death. Here we show that loss of the positive cooperativity of the yeast Cdc48p ATPase activity led to severe mitochondrial aggregation. The actin cytoskeleton and distribution of the ER-mitochondria tethering complex (ERMES) were eliminated from the cause of the mitochondrial aggregation. Instead, a mitochondrial outer membrane protein Fzo1p, which is required for mitochondrial fusion, and components of ERMES, which is involved in mitochondrial morphology, were remarkably stabilized in the Cdc48p mutants. In the last couple of years, it was shown that Vms1p functions as a cofactor of Cdc48p for the function of protein degradation of mitochondrial outer membrane proteins. Nevertheless, we found that Vms1p was not involved in the Cdc48p-dependent mitochondrial aggregation and loss of Vms1p did not significantly affect degradation rates of proteins anchored to the mitochondrial outer membrane. These results suggest that Cdc48p controls mitochondrial morphology by...Continue Reading

References

Aug 10, 2000·Molecular Biology of the Cell·L RoyJ Paiement
Feb 13, 2001·Cell·S Dalal, P I Hanson
Dec 12, 2001·Molecular Biology of the Cell·N W BaysR Y Hampton
Jan 5, 2002·Molecular and Cellular Biology·Efrat RabinovichShoshana Bar-Nun
Jan 29, 2002·Nature Cell Biology·Ernst JaroschThomas Sommer
Jul 23, 2003·Nature Biotechnology·Junmin PengSteven P Gygi
Nov 16, 2005·Annual Review of Genetics·Koji Okamoto, Janet M Shaw
May 23, 2006·Molecular Cell·Byron DeLaBarreAxel T Brunger
Jun 1, 2006·The Journal of Cell Biology·Mafalda Escobar-HenriquesThomas Langer
Sep 20, 2006·The Journal of Cell Biology·György CsordásGyörgy Hajnóczky
May 22, 2007·Biochemical and Biophysical Research Communications·Yohei SasagawaTeru Ogura
Jun 23, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Taeko KobayashiAkira Kakizuka
Mar 12, 2008·The Journal of Biological Chemistry·Louise C BriggsPaul S Freemont
Mar 21, 2008·Molecular Biology of the Cell·Mickael M J CohenAllan M Weissman
Sep 11, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Shingo NishikoriTeru Ogura
Jun 6, 2009·The International Journal of Biochemistry & Cell Biology·Louise MadsenRasmus Hartmann-Petersen
Jun 27, 2009·Science·Benoît KornmannPeter Walter
Dec 17, 2009·The Journal of Cell Biology·Jeong-Sun JuConrad C Weihl
Feb 5, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Masatoshi Esaki, Teru Ogura
Sep 22, 2010·The Journal of Cell Biology·Roswitha KrickMichael Thumm
Nov 13, 2010·Molecular Cell·Jin-Mi HeoJared Rutter
Dec 2, 2010·Molecular Biology of the Cell·Shan XuMariusz Karbowski
Dec 22, 2010·The Journal of Cell Biology·Atsushi TanakaRichard J Youle
Mar 10, 2011·Journal of Cell Science·Fabian AntonMafalda Escobar-Henriques
Apr 2, 2011·The Journal of Biological Chemistry·Shingo NishikoriTeru Ogura
Jul 12, 2011·Trends in Biochemical Sciences·Alexandra StolzDieter H Wolf
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benoît KornmannPeter Walter

❮ Previous
Next ❯

Citations

May 28, 2013·Trends in Cell Biology·Qihua Ling, Paul Jarvis
Sep 8, 2015·Current Opinion in Cell Biology·André FranzThorsten Hoppe
Apr 6, 2016·The Journal of Cell Biology·Xi WuHui Jiang
Apr 14, 2016·Cell Reports·Dmitry ZabezhinskyJeffrey E Gerst
Nov 28, 2013·Biochimica Et Biophysica Acta·Silvia CampelloFrancesco Cecconi
Dec 20, 2013·The Biochemical Journal·Joseph R Tran, Jeffrey L Brodsky
Dec 30, 2014·Antioxidants & Redox Signaling·Iryna BohovychOleh Khalimonchuk
Apr 16, 2013·Biochimica Et Biophysica Acta·André FranzThorsten Hoppe
Jun 21, 2018·Journal of Biochemistry·Abhijit ChowdhuryMasatoshi Esaki
Jan 9, 2018·ELife·Tânia SimõesMafalda Escobar-Henriques
Sep 6, 2014·The EMBO Journal·Karin B AckemaAnne Spang
Mar 3, 2020·ELife·Meredith B MetzgerAllan M Weissman
May 12, 2020·Frontiers in Cell and Developmental Biology·Sonia RavanelliThorsten Hoppe
Sep 24, 2020·International Journal of Molecular Sciences·Mafalda Escobar-Henriques, Vincent Anton
Apr 28, 2017·Open Biology·Piotr BragoszewskiAgnieszka Chacinska
Feb 27, 2014·EMBO Reports·Mafalda Escobar-Henriques, Thomas Langer
Jul 1, 2017·Frontiers in Molecular Biosciences·Yihong YeDi Xia
Oct 24, 2020·Nature Reviews. Molecular Cell Biology·Jiyao SongThomas Becker
Aug 31, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Cynthia AlsayyahMickael M Cohen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.