CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway

Frontiers in Oncology
Yixiang ZhangYing Ying

Abstract

Prostate cancer (PCa) is a major serious malignant tumor and is commonly diagnosed in older men. Identification of novel cancer-related genes in PCa is important for understanding its tumorigenesis mechanism and developing new therapies against PCa. Here, we used RNA sequencing to identify the specific genes, which are upregulated in PCa cell lines and tissues. The cell division cycle associated protein (CDCA) family, which plays a critical role in cell division and proliferation, is upregulated in the PCa cell lines of our RNA-Sequencing data. Moreover, we found that CDCA2 is overexpressed, and its protein level positively correlates with its histological grade, clinical stage, and Gleason Score. CDCA2 was further found to be upregulated and correlated with poor prognosis and patient survival in multiple cancer types in The Cancer Genome Atlas (TCGA) dataset. The functional study suggests that inhibition of CDCA2 will lead to apoptosis and lower proliferation in vitro. Silencing of CDCA2 also repressed tumor growth in vivo. Loss of CDCA2 affects several oncogenic pathways, including MAPK signaling. In addition, we further demonstrated that CDCA2 was induced in hypoxia and directly regulated by the HIF-1α/Smad3 complex. Thus, o...Continue Reading

References

Sep 14, 2002·The Journal of Biological Chemistry·Tilman Sánchez-ElsnerCarmelo Bernabéu
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Dec 14, 2004·Oncogene·Alexei L KrasnoselskyJaved Khan
Feb 24, 2006·The Journal of Cell Biology·Laura Trinkle-MulcahyAngus I Lamond
Aug 22, 2007·ACS Chemical Biology·Nicholas G NickolsPeter B Dervan
Feb 13, 2009·The Journal of Biological Chemistry·Ni ChenQiao Zhou
Aug 28, 2009·Expert Reviews in Molecular Medicine·Evon PoonMargaret Ashcroft
Nov 6, 2009·BJU International·Grant D StewartAntony C P Riddick
Feb 19, 2010·Nature·Rameen BeroukhimMatthew Meyerson
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Valérie Lallemand-Breitenbach, Hugues de Thé
Apr 3, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael MilosevicRobert Bristow
Apr 17, 2012·International Journal of Cancer. Journal International Du Cancer·Sina GrebhardtDoris Mayer
Jun 23, 2012·Nature·Catherine S GrassoScott A Tomlins
May 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brooke Bullock LaoParamjit S Arora
May 17, 2014·Frontiers in Immunology·Harm WestdorpI Jolanda M de Vries
Aug 9, 2016·International Journal of Oncology·Phung Manh ThangYataro Daigo
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 17, 2017·Nature Communications·Inês J de CastroPaola Vagnarelli
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Jan 13, 2018·Biochemical and Biophysical Research Communications·Zhengyuan ZhangGuangrong Zhou
May 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yingduan ChengCun-Yu Wang
Nov 23, 2018·Nature Communications·Suzan StellooWilbert Zwart
Jan 19, 2019·Nature Communications·Haiyang GuoHousheng Hansen He

❮ Previous
Next ❯

Citations

Feb 28, 2021·Cell Death & Disease·Xingting BaoHong Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Jimena DrukerSonia Rocha
Jul 3, 2021·Mathematical Biosciences and Engineering : MBE·Peng GuXiaoliang He

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE148544
GSE80657
GSE132827

Methods Mentioned

BETA
transfection
PCR
flow cytometry
Xenograft
flow

Software Mentioned

Ualcan

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.