PMID: 16531765Mar 15, 2006Paper

CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
Monika ZazulaJerzy Stachura

Abstract

Hypermethylation of the CDH1 promoter region seems to be the most common epigenetic mechanism in this gene silencing in gastric cancer. In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas. We introduce a new relation: clustering of Goseki grading into 3 grade was determined by CDH1 promoter hypermethylation. The percentage of methylation in Goseki III cancers was significantly higher (83%) when compared with other grades; the lowest proportion was detected in IV (36%) and II (38%) groups, whereas grade I demonstrated typical percentage of promoter hypermethylation. A novel polymorphism R732R in exon 14 of the CDH1 gene was detected by mutational analysis. Additionally, all cases with the MSI-high phenotype revealed CDH1 promoter hypermethylation. In MSI-low and MSS gastric cancers, this percentage was lower, reaching 71% and 41%, respectively. Moreover, the methylation status was correlated with the LOH phenotype. We detected CDH1 promoter hypermethylation in all EBV-positive gastric cancers (5/5), whereas methylation in the EBV-negative group occurred in 58% of cases. We also report that "methylated" tumors were slightly larger than "nonmethylated," whereas th...Continue Reading

References

Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·K YoshiuraS Hirohashi
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Oct 1, 1996·Current Opinion in Cell Biology·O HuberR Kemler
Sep 23, 1998·Human Mutation·G BerxF van Roy
Apr 17, 1999·British Journal of Cancer·J StoneR S Houlston
Sep 25, 1999·International Journal of Cancer. Journal International Du Cancer·H SuzukiK Imai
Apr 6, 2000·Journal of the National Cancer Institute·G TamuraS J Meltzer
Aug 10, 2000·The British Journal of Surgery·B P WijnhovenM Pignatelli
Sep 21, 2000·Journal of the National Cancer Institute·S B BaylinJ G Herman
Dec 10, 2002·Mechanisms of Ageing and Development·Yasuhito Yuasa
Feb 6, 2003·British Journal of Cancer·M G FontanaP Alquati
Mar 14, 2003·The Journal of Pathology·Mee Soo ChangWoo Ho Kim
May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B CarvalhoR Seruca
Sep 23, 2003·Annals of Surgery·Michael G HouseCharles J Yeo
Nov 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F GrazianoP Guilford
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Makoto SudoMasashi Fukayama
Jun 29, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Diego F CalvisiSnorri S Thorgeirsson

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Citations

Jun 10, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ChenYa Cao
Mar 20, 2018·Pathology Oncology Research : POR· PuneetGopeshwar Narayan
Apr 2, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Namrata SetiaGregory Y Lauwers
Oct 17, 2018·Epigenomics·Sadegh FattahiHaleh Akhavan-Niaki
Mar 3, 2020·Frontiers in Microbiology·Sergio GeorgeMiguel O'Ryan
May 23, 2015·Molecular Medicine Reports·Du-Guan Fu
Oct 4, 2020·Cancer Gene Therapy·Raghav ChandraMatthew Porembka
Feb 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N-Y Chia, P Tan
Jan 5, 2011·Infectious Agents and Cancer·Julie L RyanMargaret L Gulley

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