PMID: 8939471Oct 25, 1996Paper

cdk5 expression and association with p35nck5a in early stages of rat cerebellum neurogenesis; tyrosine dephosphorylation and activation in post-mitotic neurons

Neuroscience Letters
J B LazaroN J Lamb

Abstract

We have examined the expression of cyclin dependent kinase (cdk) 5 protein kinase and p35nck5a, its activator subunit, during postnatal neurogenesis in rat cerebellum, using mono-specific antibodies. Both cdk5 and p35nck5a are present and associated in proliferative stages, although cdk5-p35 kinase activity is barely detectable. Cdk5-p35 activity, but not the expression of either subunit, increases up to 6-fold during neuronal differentiation. Since we observe that cdk5 is phosphorylated on tyrosine in proliferative, but not in post-mitotic stages, we suggest that post-translational regulatory mechanisms control cdk5-p35 protein kinase activity during neurogenesis.

References

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Nov 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Dorée, S Galas
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Citations

Dec 15, 2000·Progress in Neurobiology·M F Mehler, S Gokhan
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A NishiP Greengard
Jan 27, 1998·The Journal of Biological Chemistry·Z QiJ H Wang
Nov 24, 1999·The Journal of Biological Chemistry·M NishizawaA Toh-E

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