CDK5 in oncology: recent advances and future prospects

Future Medicinal Chemistry
Jimma Likisa LenjisaShudong Wang

Abstract

Selective abrogation of cyclin-dependent kinases (CDK) activity is a highly promising strategy in cancer treatment. The atypical CDK, CDK5 has long been known for its role in neurodegenerative diseases, and is becoming an attractive drug target for cancer therapy. Myriads of recent studies have uncovered that aberrant expression of CDK5 contributes to the oncogenic initiation and progression of multiple solid and hematological malignancies. CDK5 is also implicated in the regulation of cancer stem cell biology. In this review, we present the current state of knowledge of CDK5 as a druggable target for cancer treatment. We also provide a detailed outlook of designing selective and potent inhibitors of this enzyme.

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Citations

Nov 6, 2018·Endocrine-related Cancer·Neil PortmanC Elizabeth Caldon
Aug 10, 2019·International Journal of Molecular Sciences·Muhammet OnerHo Lin
Nov 9, 2019·Biomedicines·Rabih Roufayel, Nimer Murshid
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May 1, 2021·International Journal of Molecular Sciences·Brianna ChenAriadna Recasens
May 18, 2019·ACS Medicinal Chemistry Letters·Nishat Z KhairShudong Wang

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BETA
Xenograft
xenografts

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