Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells

Journal of Cellular Physiology
Giulia De FalcoAntonio Giordano

Abstract

Cdk9/Cyclin T1 complex is very important in controlling specific differentiative pathways of several cell types. Limited data are available regarding the expression of Cdk9/Cyclin T1 in hematopoietic and lymphoid tissues. Cdk9/Cyclin T1 expression seems to be related to particular stages of lymphoid differentiation/activation. In this study, we observed that the expression level of Cdk9/Cyclin T1 in vivo increases in memory B cells compared to naïve B cells, and in activated B cells, compared to non-activated ones. The expression level of the Cdk9/Cyclin T1 complex does not increase in cells induced to differentiate in vitro. In addition, we showed that Cdk9 interacts with E12 and E47, specifically activated during Germinal Center (GC) reaction. Taken together this data suggests an active role for the Cdk9/Cyclin T1 complex during lymphoid differentiation through germinal center reaction.

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Citations

Aug 30, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marialucia GalloriniViviana di Giacomo
Jun 17, 2009·International Journal of Cancer. Journal International Du Cancer·Eleonora LeucciLorenzo Leoncini
Aug 12, 2016·Scientific Reports·Annelie HellvardPiotr Mydel
Jul 20, 2017·Journal of Cellular Biochemistry·Lia Carolina FrancoAntonio Giordano
Oct 27, 2018·Current Drug Targets·Shirin EyvaziVahideh Tarhriz

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