CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population

BMC Genetics
Tran Quang BinhTrinh Thi Hong Nhung

Abstract

People with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex disorder involving both genetic and environmental factors in its pathogenesis. This cross-sectional study aimed to investigate the independent risk factors for prediabetes, considering the contribution of genetic factors (TCF7L2-rs7903146, IRS1-rs1801278, INSR-rs3745551, CDKN2A-rs10811661, and FTO-rs9939609), socio-economic status, and lifestyle factors. Among the candidate genes studied, the CDKN2A-rs10811661 polymorphism was found to be the most significant factor associated with prediabetes in the model unadjusted and adjusted for age, sex, obesity-related traits, systolic blood pressure, dyslipidemia, socio-economic status, and lifestyle factors. In the final model, the CDKN2A-rs10811661 polymorphism (OR per T allele = 1.22, 95 % CI = 1.04-1.44, P = 0.017), systolic blood pressure (OR per 10 mmHg = 1.14, 95 % CI = 1.08-1.20, P < 0.0001), waist-hip ratio (OR = 1.25, 95 % CI = 1.10-1.42, P < 0.0001), dyslipidemia (OR = 1.57, 95 % CI = 1.15-2.14, P = 0.004), and residence (OR = 1.93, 95 % CI = 2.82-4.14, P < 0.0001) were the ...Continue Reading

References

Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 5, 2002·Diabetes Research and Clinical Practice·Takeshi KuzuyaUNKNOWN Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Jan 30, 2007·Diabetes Care·Gregory A NicholsJonathan B Brown
Mar 1, 2007·Diabetes Care·David M NathanUNKNOWN American Diabetes Association
Aug 19, 2007·BMC Genomics·Pongsakorn WangkumhangSissades Tongsima
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Sep 29, 2011·BMC Public Health·Amina KhambaliaAdrian E Bauman
Feb 14, 2012·American Journal of Human Genetics·Richa SaxenaBrendan J Keating
Aug 16, 2013·Human Molecular Genetics·Kazuo HaraTakashi Kadowaki
Feb 11, 2014·Nature Genetics·UNKNOWN DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) ConsortiumAndrew P Morris
Apr 11, 2014·International Journal of Endocrinology·Kevin J BasileStruan F A Grant
Oct 9, 2014·Endocrine·Martin BuysschaertJaqueline Lonier

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Citations

Dec 7, 2016·Antimicrobial Agents and Chemotherapy·Nguyen Tien HuyKenji Hirayama
Jan 13, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·M TarnowskiA Pawlik
Jan 15, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Amit K VermaArshad Husain Rahmani

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Methods Mentioned

BETA
genotyping

Software Mentioned

Bayesian Model Averaging
R Statistical Environment
SPSS

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