CDKN2A testing and genetic counseling promote reductions in objectively measured sun exposure one year later

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Tammy StumpSancy A Leachman

Abstract

This study investigated whether genetic counseling and test reporting for the highly penetrant CDKN2A melanoma predisposition gene promoted decreases in sun exposure. A prospective, nonequivalent control group design compared unaffected participants (N = 128, Mage = 35.24, 52% men) from (1) families known to carry a CDKN2A pathogenic variant, who received counseling about management recommendations and a positive or negative genetic test result and (2) no-test control families known not to carry a CDKN2A pathogenic variant, who received equivalent counseling based on their comparable family history. Changes in daily ultraviolet radiation (UVR) exposure (J/m2), skin pigmentation (melanin index), and sunburns between baseline and one year following counseling were compared among carriers (n = 32), noncarriers (n = 46), and no-test control participants (n = 50). Both carriers and no-test control participants exhibited a decrease one year later in daily UVR dose (B = -0.52, -0.33, p < 0.01). Only carriers exhibited a significant decrease in skin pigmentation at the wrist one year later (B = -0.11, p < 0.001), and both carriers and no-test control participants reported fewer sunburns than noncarriers (p < 0.05). Facial pigmentation ...Continue Reading

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Citations

May 18, 2020·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jennifer M TaberSancy A Leachman
Feb 16, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Clare A PrimieroAideen M McInerney-Leo

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