PMID: 8605247Feb 7, 1996Paper

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure

Biochimica Et Biophysica Acta
A RoglicR D Ye

Abstract

A cDNA designated as AZ3B has been isolated from a differentiated HL-6 0 cell cDNA library with a probe derived from the N-formyl peptide receptor gene. The 1.97-kb cDNA encodes a novel G protein-coupled receptor (GPCR) with 482 amino acids. In addition to the predicted 7 transmembrane domains common to all GPCRs, the protein encoded by AZ3B contains a large extracellular loop of approximately 172 amino acids between the fourth and the fifth transmembrane domains, a feature unique among the hundreds of GPCRs identified to date. High sequence homology exists between the AZ3B protein and a number of chemoattractant receptors in the amino-terminal 170 residues and the carboxyl-terminal 150 residues. Northern and flow cytometric analyses suggested that the AZ3B message and protein are widely expressed in several differentiated hematopoietic cell lines, in the lung, placenta, heart, and endothelial cells. We postulate that the AZ3B protein defines a distinct group of receptors within the GPCR superfamily.

References

Apr 30, 1992·Biochemical and Biophysical Research Communications·R D YeC G Cochrane
Oct 15, 1991·Biochemical and Biophysical Research Communications·R D YeC G Cochrane
May 16, 1990·Biochemical and Biophysical Research Communications·F BoulayP Vignais
Dec 22, 1989·Science·M ParmentierG Vassart
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·S NystedtJ Sundelin

❮ Previous
Next ❯

Citations

Sep 21, 2004·Invertebrate Neuroscience : in·R Elwyn IsaacAlan D Shirras
Jul 25, 2000·Immunopharmacology·A Sahu, J D Lambris
Feb 26, 1998·Immunopharmacology·R S AmesH M Sarau
Feb 26, 1998·Immunopharmacology·J A Ember, T E Hugli
Apr 3, 2003·Brain Research. Molecular Brain Research·S SayahM Fontaine
Jun 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·V Michael Holers
Dec 14, 1999·Protein Science : a Publication of the Protein Society·J SunT E Hugli
Aug 15, 1998·Annals of the New York Academy of Sciences·F BoulayL Brouchon
Nov 28, 2007·International Immunopharmacology·Richard G DiScipio, Ingrid U Schraufstatter
Jun 10, 2003·Annals of the New York Academy of Sciences·Johan van BeekPhilippe Gasque
May 1, 2004·Surgery·Tsukasa TakabayashiJeffrey A Gelfand
Sep 13, 2005·Immunology Letters·Marie-Claude MathieuAlex G Therien
Jul 21, 1997·The Journal of Experimental Medicine·U MartinA Klos
Aug 23, 1996·The Journal of Biological Chemistry·R S AmesC Kumar
Nov 19, 2004·The New England Journal of Medicine·Sandeep S DaveLouis M Staudt
Feb 8, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stacey L Mueller-OrtizRick A Wetsel
Aug 31, 1999·Immunopharmacology and Immunotoxicology·M A Panaro, V Mitolo
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniela MelilloMaria Rosaria Pinto
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiphaine MonsinjonMarc C Fontaine
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingrid U SchraufstatterSophia K Khaldoyanidi
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T WerfelJ Zwirner
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R S AmesH M Sarau
Jul 23, 2003·The Journal of Biological Chemistry·Jinming GaoNorma P Gerard
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura BoosScott R Barnum
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carol B Martin, Brian K Martin
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H PeteringJ Elsner
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Rosaria PintoJohn D Lambris
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hani BoshraJ Oriol Sunyer
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afsaneh SoruriJörg Zwirner
Oct 3, 1999·Physiological Reviews·A J Morris, C C Malbon
Aug 26, 1998·European Journal of Immunology·D ParalW Bautsch
Sep 24, 1999·Biochemical and Biophysical Research Communications·Y FukuokaT E Hugli
Feb 17, 1998·Biochemical and Biophysical Research Communications·Y FukuokaT E Hugli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.