cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance

Cancer Chemotherapy and Pharmacology
Goli SamimiStephen B Howell

Abstract

In order to identify genes whose expression is associated with resistance to the chemotherapeutic agent oxaliplatin, transcripts differentially expressed between an oxaliplatin sensitive and a stably resistant subline were compared in six independent replicates using Stanford cDNA microarrays for five cell lines. "Significance analysis of microarrays" (SAM) was used to identify genes whose expression was statistically significantly different in the sensitive versus resistant members of each cell line pair. The biochemical pathways of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database were searched to identify those pathways in which the number of SAM-identified genes exceeded the number expected. This identified four pathways in which upregulated genes were significantly associated with resistance in two of the cell line pairs, and two pathways in which the association was found in three cell line pairs. The search also identified 12 pathways in which downregulated genes were associated with resistance in two cell line pairs and one pathway in which the association reached statistical significance in three cell line pairs. Pathways identified included the ribosome pathway, the Huntington's disease pathway that includes...Continue Reading

References

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·R E JohnsonL Prakash
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C FriedbergV L Gerlach
Aug 11, 2000·Critical Reviews in Oncology/hematology·J L MissetE Cvitkovic
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jun 7, 2002·Critical Reviews in Oncology/hematology·Bernard Desoize, Claudie Madoulet
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M MishimaS B Howell
Oct 23, 2002·Molecular Pharmacology·Xinjian LinStephen B Howell
Dec 19, 2002·Environmental and Molecular Mutagenesis·Henriqueta LouroMaria G Boavida
Jan 2, 2003·DNA Repair·Christopher W Lawrence
Jan 10, 2003·Nucleic Acids Research·Maximilian DiehnAsh A Alizadeh

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Citations

Jul 4, 2012·Oncogene·V CarloniS Capaccioli
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A P G CrijnsE G E de Vries
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M L DisisJ S Berek
Jan 26, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B GyörffyH Lage
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S FuR C Bast
Aug 23, 2011·International Journal of Cancer. Journal International Du Cancer·Tibor FeketeBalázs Györffy
Oct 20, 2005·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Alan Richardson, Stan B Kaye
Jul 24, 2008·Nature Clinical Practice. Oncology·Panagiotis A KonstantinopoulosStephen A Cannistra
Jul 1, 2005·Plant Molecular Biology·Frédérique PasquerBeat Keller
Nov 6, 2007·Immunological Reviews·A Karolina PaluckaJacques Banchereau
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony D YangLee M Ellis

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