PMID: 9431815Feb 12, 1998Paper

cDNA sequence and expression pattern of the Drosophila melanogaster PAPS synthetase gene: a new salivary gland marker

Mechanisms of Development
D JullienE Käs

Abstract

PAPS synthetase is a bifunctional enzyme containing both ATP sulfurylase and APS kinase activities required for the biosynthesis of PAPS, the sulfate donor in sulfation reactions. Here we report the sequence of the Drosophila melanogaster PAPS synthetase, the first gene implicated in the sulfation pathway to be described in that organism, and the characterization of its specificity of expression in embryos. Whole-mount in situ hybridization reveals that DmPAPSS is a novel salivary gland marker. At the end of embryogenesis, expression of DmPAPSS is also observed at the entry and exit of the gut and the posterior spiracles. We discuss the possibility that the pattern of expression of the DmPAPSS gene might reflect a major role for sulfation in mucus biosynthesis at the end of Drosophila embryogenesis.

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Citations

Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P L BradleyD J Andrew
May 14, 2003·Trends in Cell Biology·Elliott W AbramsDeborah J Andrew
Jul 10, 1999·The International Journal of Biochemistry & Cell Biology·V L FranzonE G Cleary
Jul 9, 2005·Development Genes and Evolution·Reda A AliStefan Baumgartner
Mar 8, 2000·Mechanisms of Development·D J AndrewP Seshaiah
Jan 8, 2000·Developmental Biology·K D Henderson, D J Andrew
Oct 10, 2002·Endocrine Reviews·Charles A Strott
Jul 29, 2006·The Journal of Biological Chemistry·Emi GodaShoko Nishihara
Feb 5, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S BessetJ P Girard
Dec 15, 2006·Development·Stefanie D HueberIngrid Lohmann

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