PMID: 11311946Apr 20, 2001Paper

cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain

Biochimica Et Biophysica Acta
N OkamotoSaburo Onishi

Abstract

A full-length cDNA clone of human carbonic anhydrase-related protein (CA-RP) X was obtained and sequenced. The 2720 bp long cDNA sequence was predicted to encode a 328 amino acid polypeptide. The deduced amino acid sequence showed an overall similarity of 25-57% to other CA isozymes and the highest % similarity to a CA-RP XI. Similar to CA-RP XI, CA-RP X lacked two out of three zinc-liganded histidine residues, suggesting no biological activity of CA. Northern blot analysis demonstrated an approx. 2.8 kb transcript in the human brain and kidney. RNA dot blotting showed significant signals for CA-RP X and XI mRNA expressions in the adult total brain and almost all parts of the central nervous system, but no expression in the fetal brain. These results suggest that CA-RP X and XI play some role in human brain, especially in brain development.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T OkuyamaW S Sly
Jan 1, 1992·Advances in Genetics·R E Tashian
Mar 11, 1987·Nucleic Acids Research·J H BarlowP H Butterworth
Jan 1, 1984·Annals of the New York Academy of Sciences·W R ChegwiddenR E Tashian
Jun 1, 1983·European Journal of Biochemistry·G von Heijne
Jan 1, 1995·Annual Review of Biochemistry·W S Sly, P Y Hu
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y NagaoW S Sly
Aug 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Kozak
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·O TüreciW S Sly
Jan 8, 1999·Biochemical and Biophysical Research Communications·J BellinghamC Y Gregory-Evans
Jan 28, 1999·Human Genetics·J J KleiderleinR L Margolis

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Citations

Jun 9, 2005·Virchows Archiv : an International Journal of Pathology·Kaori MorimotoSaburo Onishi
Jan 18, 2003·Brain Research. Molecular Brain Research·Keisuke TaniuchiSaburo Onishi
Jul 14, 2007·BMC Genomics·Murat CankayaOmer Irfan Kufrevioglu
Apr 2, 2010·BMC Molecular Biology·Ashok AspatwarSeppo Parkkila
Nov 18, 2008·Journal of Gastroenterology·Saori MorishitaClaudiu T Supuran
Dec 14, 2006·Kidney International·J M Purkerson, G J Schwartz
Dec 1, 2007·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·A J Esbaugh, B L Tufts
Jan 9, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Ashok AspatwarSeppo Parkkila
Jul 31, 2012·European Journal of Medical Genetics·E PreiksaitieneV Kučinskas
Aug 2, 2011·Biochimica Et Biophysica Acta·Meghan E McDevitt, Lisa A Lambert
Sep 1, 2015·Molecular and Cellular Endocrinology·Milica VujovicJens Mittag
Jun 15, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K M Gilmour
Sep 2, 2003·The Journal of Pathology·Eiki MiyajiSaburo Onishi
Jan 16, 2007·Molecular Carcinogenesis·Makoto NishikataSaburo Onishi
Nov 13, 2003·Physiological Genomics·David D L Woo, Ira Kurtz

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