PMID: 9186694Apr 5, 1997Paper

CDRH3 length is the target of selection of disease-associated IgM autoantibodies

Annals of the New York Academy of Sciences
V LipsanenA Kaushik

Abstract

The experiments outlined here provide evidence for positive selection of B-1 lymphocytes secreting IgM autoantibodies in the autoimmune mev mice as a result of the reduced threshold of responsiveness to autoantigens because of PTP1C deficiency, which is targeted at the CDR3 length of the variable region of the heavy chain. In addition, characteristic differences in the size, hydrophobicity pattern, and relative local charge of the CDR3 of the heavy chain of disease-associated IgM autoantibodies from moth-eaten mice help distinguish them from physiological natural autoantibodies present in normal mice.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KaushikG Kelsoe
Oct 1, 1988·Journal of Autoimmunity·B M BrökerP Collins
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A M StallL A Herzenberg
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle

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Citations

Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel J LaydonBecca Asquith

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