Cdrom Archive: A Gateway to Study Camel Phenotypes

Frontiers in Genetics
Hasan Alhaddad, Bader H Alhajeri

Abstract

Camels are livestock that exhibit unique morphological, biochemical, and behavioral traits, which arose by natural and artificial selection. Investigating the molecular basis of camel traits has been limited by: (1) the absence of a comprehensive record of morphological trait variation (e.g., diseases) and the associated mode of inheritance, (2) the lack of extended pedigrees of specific trait(s), and (3) the long reproductive cycle of the camel, which makes the cost of establishing and maintaining a breeding colony (i.e., monitoring crosses) prohibitively high. Overcoming these challenges requires (1) detailed documentation of phenotypes/genetic diseases and their likely mode of inheritance (and collection of related DNA samples), (2) conducting association studies to identify phenotypes/genetic diseases causing genetic variants (instead of classical linkage analysis, which requires extended pedigrees), and (3) validating likely causative variants by screening a large number of camel samples from different populations. We attempt to address these issues by establishing a systematic way of collecting camel DNA samples, and associated phenotypic information, which we call the "Cdrom Archive." Here, we outline the process of buil...Continue Reading

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Citations

Jun 13, 2020·The Journal of Heredity·Huda AlAskarHasan Alhaddad

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Software Mentioned

SamplEase
ggmap R
R Development Core Team
Cdrom
Cdrom Archive

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