CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions

Journal of Gastroenterology and Hepatology
Hyung-Seok KimChang-Soo Park

Abstract

Recent studies have demonstrated that CDX-2 is expressed in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. To address the role of CDX-2 in carcinogenesis of gastric carcinomas of intestinal type, the expression of CDX-2 in gastric carcinoma and precursor lesions were examined using immunohistochemistry. A total of 160 specimens diagnosed as gastric carcinomas or non-invasive neoplasia from 158 patients were analyzed for CDX-2 expression by immunochemical methods. Patients were classified into histopathologic subgroups according to the Padova international classification: 60 cases of low-grade non-invasive neoplasia, 55 cases of high grade, and 45 cases of invasive intestinal-type adenocarcinoma. The CDX-2 expression in non-neoplastic gastric mucosa including intestinal metaplasia was also evaluated in the areas included in the histologic sections. The CDX-2 expression was localized in the epithelial cell nuclei in the area of intestinal metaplasia with or without dysplasia and carcinoma, consistent with its role as a transcriptional regulator. No CDX-2 reactivity was noted in the normal mucosa in all cases. The CDX-2 expression was detected in 73.3% of low-grade cases, 85.5% of high-grade cases and...Continue Reading

References

May 1, 1994·International Journal of Cancer. Journal International Du Cancer·M I FilipeT Prijon
Feb 1, 1996·Molecular and Cellular Biology·E Suh, P G Traber
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F BeckJ B Furness
Feb 19, 2000·The American Journal of Surgical Pathology·M RuggeH Watanabe
Oct 21, 2000·Gastroenterology·D G SilbergP G Traber
Apr 17, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Si-Chun Ming
Oct 15, 2003·Journal of Cancer Research and Clinical Oncology·Tsutomu MizoshitaMasae Tatematsu
Nov 3, 2004·Cancer Research·Hiroyuki MutohKentaro Sugano

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Citations

Oct 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Do Youn ParkGregory Y Lauwers
Jan 7, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sheng-Nan JiangJung-Joon Min
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggageH A McBride
Sep 12, 2006·Journal of Clinical Pathology·Carlos A Rubio
Jul 25, 2012·BMC Cancer·Bhagyalaxmi Sukka-GaneshNajmunnisa Nasreen
Mar 1, 2012·Gut and Liver·Byoung Hwan LeeIn Sung Song
Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Massimo RuggeMatteo Fassan
Mar 21, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·Jie GeZihua Chen
Nov 28, 2012·Journal of Experimental & Clinical Cancer Research : CR·Xiao-Tong WangYu-Bo Xie
Nov 23, 2011·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Bo-Gun Jang, Woo Ho Kim
May 3, 2011·Journal of Korean Medical Science·Jung Mook KangIn Sung Song
May 24, 2007·International Journal of Cancer. Journal International Du Cancer·Akiko ShiotaniJuanita L Merchant
Feb 16, 2016·World Journal of Gastroenterology : WJG·Amanda Ferreira VidalÂndrea Ribeiro-dos-Santos
Apr 29, 2016·Oncology Letters·Junli MaShan Zeng

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