CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition

Developmental Biology
Jessie ChangRobert K Ho

Abstract

The sub-division of the posterior-most territory of the neural plate results in the formation of two distinct neural structures, the hindbrain and the spinal cord. Although many of the molecular signals regulating the development of these individual structures have been elucidated, the mechanisms involved in delineating the boundary between the hindbrain and spinal cord remain elusive. Two molecules, retinoic acid (RA) and the Cdx4 transcription factor have been previously implicated as important regulators of hindbrain and spinal cord development, respectively. Here, we provide evidence that suggests multiple regulatory interactions occur between RA signaling and the Cdx4 transcription factor to establish the anterior-posterior (AP) position of the transition between the hindbrain and spinal cord. Using chemical inhibitors to alter RA concentrations and morpholinos to knock-down Cdx4 function in zebrafish, we show that Cdx4 acts to prevent RA degradation in the presumptive spinal cord domain by suppressing expression of the RA degradation enzyme, Cyp26a1. In the hindbrain, RA signaling modulates its own concentration by activating the expression of cyp26a1 and inhibiting the expansion of cdx4. Therefore, interactions between C...Continue Reading

References

Aug 1, 1991·Current Opinion in Genetics & Development·P Gruss, M Kessel
May 1, 1990·Neuron·B TrevarrowC B Kimmel
Oct 1, 1993·Journal of Neurobiology·R KrumlaufA Lumsden
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P DolléP Chambon
Jul 13, 2000·Current Opinion in Genetics & Development·A Gavalas, R Krumlauf
Feb 17, 2001·Current Opinion in Neurobiology·M Rhinn, M Brand
Mar 17, 2001·Nature Reviews. Neuroscience·C D Stern
Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T F Schilling, R D Knight
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Kristin R MeltonPaul A Trainor
Apr 28, 2004·Mechanisms of Development·Betsy Dobbs-McAuliffeElwood Linney
Jan 29, 2005·The Journal of Biological Chemistry·Mélanie Béland, David Lohnes
Feb 15, 2005·Developmental Biology·Takashi ShimizuMasahiko Hibi
Jun 28, 2005·Gene Expression Patterns : GEP·Xingxing GuQingshun Zhao
Aug 17, 2005·Developmental Biology·Lisa Maves, Charles B Kimmel
Jul 27, 2007·Developmental Biology·Monica R RohrschneiderVictoria E Prince
Feb 1, 2008·Development·Mary D KinkelVictoria E Prince
Feb 11, 2010·Developmental Biology·Beena PunnamoottilSilke Rinkwitz
Sep 4, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Albert G HaywardIsaac Skromne

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Citations

Dec 7, 2018·Cellular and Molecular Life Sciences : CMLS·Dale Frank, Dalit Sela-Donenfeld
Mar 3, 2019·Developmental Biology·Piyush JoshiIsaac Skromne

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