PMID: 1202621Jan 1, 1975Paper

CEA levels at recurrence and metastases; importance for detecting secondary disease

Scandinavian Journal of Gastroenterology
A Rieger, B Wahren

Abstract

The relation of CEA plasma levels to prognostic factors was studied in 170 patients with various stages of colo-rectal cancer. Several parameters of known relevance for the prognosis were analyzed. Among the patients with involvement of regional lymph nodes at the time of the primary, 53% had a raised CEA value (greater than 5 ng/ml serum) as opposed to 21% when this was not the case (p less than 0.05%). When serosal break-through had occured, 47% of the patients had raised values compared to 21% of those with no serosal break-through (p less than 0.02%). After radical surgery, all patients who remained healthy acquired persistent low plasma CEA, giving the assay a prognostic value. Altogether 20 patients had local recurrences without distant metastases and were thus potential candidates for a re-operation for cure. 70% had raised CEA plasma values, giving the assay a better than expected usefulness in the clinical follow-up, the significance of the difference from operated and healthy patients or healthy control persons being high, p less than 0.001%. The secondary rise in CEA appeared to be unconnected with whether or not the primary tumor had been accompanied by raised plasma CEA. The localization and the histopathological d...Continue Reading

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