PMID: 1203857Dec 1, 1975Paper

CEA levels in patients with colorectal polyps

Cancer
W G DoosN Zamcheck

Abstract

Preoperative plasma CEA levels were measured in 93 selected patients with histologically defined colorectal adenomata removed at fibroptic colonoscopy in order to determine whether CEA levels are elevated in patients with colonic polyps, or vary with different histologic patterns. None of the patients had inflammatory bowel disease, previous history of carcinoma, or evidence of liver disease. Fifteen percent of the patients had elevated CEA levels (greater than or equal to 2.5 ng/ml; Hansen method), and two-thirds of these were between 2.5 and 4.0 ng/ml. Increased association of elevated CEA levels was noted with old age, villous adenomas (2- to 4-fold), and increased tumor size (greater than 2.3-cm diameter; 2-fold), but not with foci of dysplasia or carcinoma in situ as such. One-half (7/14) of the patients with elevated CEA levels showed the following: two patients had villous tumors with carcinoma in situ, one had a villous adenoma, two had mixed villous and tubular adenomas (with a high proportion of villous pattern), and two were subsequently shown to have carcinoma elsewhere in the colon. It is uncertain that the polyps were the source of the elevated circulating CEA levels; other factors including smoking and patient se...Continue Reading

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Citations

Oct 1, 1990·Clinical Biochemistry·M K Schwartz
Nov 1, 1992·The American Journal of Medicine
Sep 1, 1985·Cancer Treatment Reviews·S E Bates, D L Longo
Jan 1, 1986·American Journal of Surgery·F C AuC K Tang
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Jul 1, 1984·Annals of Clinical Biochemistry·R H Begent

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