PMID: 64132Jan 1, 1977Paper

CEA monitoring of palliative treatment for colorectal carcinoma

Annals of Surgery
M A HerreraA Mittelman

Abstract

Palliative treatment was applied to 131 cases of unresectable or palliatively resected colorectal carcinoma being monitored with serial CEA determinations. There were 84 instances of disease progression with 67 (80%) of them showing an increase in CEA above pretreatment levels or maintaining high levels, and 17 (20%) showing a fall when compared to pretreatment values or maintaining low initial values. There was a clear-cut regression of the disease in only 9 instances. In all 9, the CEA clearly dropped or maintained low valles throughout the period of regression. No patient in regression had a rise or maintained an elevated CEA level. These changes in CEA followed closely the clinical response of our patient to the use of a particular agent, although for the Nitrosourea compounds there may be a tendency to lower the CEA regardless of the patient's tumor response to the drug. This could be due to the fact that the Nitrosoureas produce a diffuse block of cellular activity, both at the nucleous and cytoplasm; while other compounds act as alkylating agents or by inhibition of enzymes involved in the metabolism of nucleic acids (i.e., 5-FU inhibiting thymidylate synthetase). In general, longer survival was found in those patients w...Continue Reading

References

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Citations

Apr 1, 1982·Diseases of the Colon and Rectum·J J SzymenderaA W Szawowski
Jun 12, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·V Trillet-LenoirJ P Bleuse
Jul 11, 1998·Journal of the American College of Surgeons·M TachibanaN Nagasue
Sep 1, 1985·Cancer Treatment Reviews·S E Bates, D L Longo
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M KouriS Pyrhönen
Aug 1, 1981·Current Problems in Cancer·E D HolyokeM S Arnott
Aug 1, 1987·International Journal of Oral and Maxillofacial Surgery·K ShirasunaY Hayashido
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annie On-On ChanJohn Wong
Sep 1, 1978·Cancer·J T EvansE D Holyoke
Oct 1, 1977·The Australian and New Zealand Journal of Surgery·B N GrayR C Bennett
Jan 1, 1989·Seminars in Surgical Oncology·J P Minton, A Chevinsky
Aug 17, 2005·Cancer Investigation·Mitchell J Goldstein, Edith Peterson Mitchell
Jul 1, 1984·Annals of Clinical Biochemistry·R H Begent
Feb 1, 1982·Current Problems in Surgery·H P EwingJ D Hardy

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