CEACAM1 regulates CD8+ T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis.

Gut Microbes
Astrid M WestendorfAstrid M Westendorf

Abstract

The incidence of gastrointestinal infections continues to increase, and infectious colitis contributes significantly to morbidity and mortality worldwide. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been discovered to be strongly involved in the intestinal homeostasis. However, whether intestinal CEACAM1 expression has an impact on the control of infectious colitis remains elusive. Citrobacter rodentium (C. rodentium) is a gram-negative enteric pathogen that induces colonic inflammation in mice, with a critical role for CD4+ T cell but not CD8+ T cell immunity to primary infection. Here, we show that Ceacam1-/- mice are much more susceptible to C. rodentium infection than wildtype mice, which is mediated by a defect in the intestinal barrier and, surprisingly, by a dysregulated CD8+ T cell but not CD4+ T cell response in the colon. CEACAM1 expression is essential for the control of CD8+ T cell immunity, as CEACAM1 deficiency during C. rodentium infection inhibits CD8+ T cell exhaustion. We conclude that CEACAM1 is an important regulator of CD8+ T cell function in the colon, and blocking CEACAM1 signaling to activate CD8+ T cells may have unforeseen side effects.

References

Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Mar 15, 1996·International Journal of Cancer. Journal International Du Cancer·M J MollerS von Kleist
Apr 29, 1998·Annual Review of Physiology·J L Madara
Sep 29, 2000·European Journal of Immunology·A DondaG De Libero
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi NakajimaRichard S Blumberg
Feb 19, 2004·The Journal of Experimental Medicine·Hideki IijimaRichard S Blumberg
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daohong ChenRichard S Blumberg
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens BrimnesLloyd Mayer
Nov 29, 2005·Cellular Microbiology·Rosanna MundySiouxsie Wiles
May 26, 2006·Nature Reviews. Immunology·Scott D Gray-Owen, Richard S Blumberg
Aug 22, 2006·Current Opinion in Cell Biology·Katharina KuespertChristof R Hauck
Nov 4, 2006·Immunity·Takashi NagaishiRichard S Blumberg
May 26, 2007·The Journal of Clinical Investigation·Nicolas BarnichArlette Darfeuille-Michaud
Sep 4, 2007·Applied and Environmental Microbiology·Christian U RiedelColin Hill
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhangguo ChenRichard S Blumberg
Jul 16, 2008·Inflammatory Bowel Diseases·Michael A McGuckinGraham Radford-Smith
Apr 22, 2010·BMC Microbiology·Maike VogesChristof R Hauck
Sep 22, 2010·Current Opinion in Gastroenterology·Udayakumar Navaneethan, Ralph A Giannella
Dec 27, 2011·Current Topics in Medicinal Chemistry·S SapoznikG Markel
Jun 8, 2012·Annals of the New York Academy of Sciences·Christopher R Weber
Oct 20, 2012·Nature Reviews. Immunology·Susan M Kaech, Weiguo Cui
Apr 17, 2014·Cell Communication and Signaling : CCS·Arnaud Kengmo TchoupaChristof R Hauck
Nov 5, 2014·Nature·Yu-Hwa HuangRichard S Blumberg
Feb 19, 2015·Nature Communications·Vishal KhairnarKarl S Lang
Apr 22, 2015·The New England Journal of Medicine·Michael A PostowF Stephen Hodi
Apr 25, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasuaki KitamuraTakashi Matozaki
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok
Jul 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Virginia SeiffartAstrid M Westendorf

❮ Previous
Next ❯

Citations

Nov 12, 2020·American Journal of Reproductive Immunology : AJRI·Pawel MachAngela Köninger
Aug 10, 2021·Frontiers in Molecular Biosciences·Fan YangFeng Wei

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
pull down
FCS
flow cytometry
PMA
biopsies
pull-down

Software Mentioned

Luminex IS

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.