CeasIng Cpap At standarD criteriA (CICADA): impact on weight gain, time to full feeds and caffeine use

Archives of Disease in Childhood. Fetal and Neonatal Edition
Margaret BroomDavid A Todd


In our previous randomised controlled trial (RCT), we have shown in preterm babies (PBs) <30 weeks gestation that CeasIng Cpap At standarD criteriA (CICADA (method 1)) compared with cycling off continuous positive airway pressure (CPAP) gradually (method 2) or cycling off CPAP gradually with low flow air/oxygen during periods off CPAP (method 3) reduces CPAP cessation time in PBs <30 weeks gestation. This retrospective study reviewed weight gain, time to reach full feeds and time to cease caffeine in PBs previously enrolled in the RCT. Data were collected from 162 of the 177 PBs, and there was no significant difference in the projected weight gain between the three methods. Based on intention to treat, the time taken to reach full feeds for all three methods showed no significant difference. However, post hoc analysis showed the CICADA method compared with cycling off gradually just failed significance (30.3±1.6 vs 31.1±2.4 (weeks corrected gestational age (Wks CGA±SD)), p=0.077). Analysis of time to cease caffeine showed there was a significant difference between the methods with PBs randomised to the CICADA method compared with the cycling off method ceasing caffeine almost a week earlier (33.6±2.4 vs 34.5±2.8 (Wks CGA±SD), p...Continue Reading


Oct 21, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·R J Cooke, N D Embleton
Dec 5, 2002·Seminars in Neonatology : SN·Richard A Polin, Rakesh Sahni
Apr 30, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·A G De PaoliP G Davis
May 19, 2006·The New England Journal of Medicine·Barbara SchmidtUNKNOWN Caffeine for Apnea of Prematurity Trial Group
May 23, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·David A ToddB Shadbolt

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