C/EBPβ Promotes Immunity to Oral Candidiasis through Regulation of β-Defensins

PloS One
Michelle R Simpson-AbelsonSarah L Gaffen

Abstract

Humans or mice subjected to immunosuppression, such as corticosteroids or anti-cytokine biologic therapies, are susceptible to mucosal infections by the commensal fungus Candida albicans. Recently it has become evident that the Th17/IL-17 axis is essential for immunity to candidiasis, but the downstream events that control immunity to this fungus are poorly understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) transcription factor is important for signaling by multiple inflammatory stimuli, including IL-17. C/EBPβ is regulated in a variety of ways by IL-17, and controls several downstream IL-17 target genes. However, the role of C/EBPβ in vivo is poorly understood, in part because C/EBPβ-deficient mice are challenging to breed and work with. In this study, we sought to understand the role of C/EBPβ in the context of an IL-17-dependent immune response, using C. albicans infection as a model system. Confirming prior findings, we found that C/EBPβ is required for immunity to systemic candidiasis. In contrast, C/EBPβ(-/-) mice were resistant to oropharyngeal candidiasis (OPC), in a manner indistinguishable from immunocompetent WT mice. However, C/EBPβ(-/-) mice experienced more severe OPC than WT mice in the context of cortison...Continue Reading

References

Oct 16, 2001·Antimicrobial Agents and Chemotherapy·Y KamaiS G Filler
May 15, 2002·The Biochemical Journal·Dipak P Ramji, Pelagia Foka
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Yuan KaoReen Wu
Sep 4, 2004·The Journal of Infectious Diseases·David A SchofieldEdward Balish
Jun 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qi-Qun TangM Daniel Lane
Jun 27, 2006·The Journal of Biological Chemistry·Fang ShenSarah L Gaffen
Apr 26, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amarnath MaitraSarah L Gaffen
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi UematsuShizuo Akira
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dolores M CortezBysani Chandrasekar
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fei HuangReen Wu
Feb 11, 2009·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allen W HoSarah L Gaffen
Aug 3, 2010·Current Opinion in Immunology·Anne PuelJean-Laurent Casanova
Oct 23, 2010·Current Opinion in Allergy and Clinical Immunology·Sarah K Browne, Steven M Holland
Feb 25, 2011·Mucosal Immunology·H R ContiS L Gaffen
Mar 1, 2012·Cellular Signalling·René HuberKorbinian Brand
Mar 10, 2012·Nature Protocols·Norma V Solis, Scott G Filler
May 23, 2012·Cell Host & Microbe·Nydiaris Hernández-Santos, Sarah L Gaffen
Jul 31, 2012·Arthritis Research & Therapy·Anna R HupplerSarah L Gaffen
Dec 20, 2012·Mucosal Immunology·N Hernández-SantosS L Gaffen
Dec 21, 2012·Science Translational Medicine·Gordon D BrownTheodore C White
Jul 28, 2013·Nature Reviews. Immunology·Joshua D Milner, Steven M Holland
Dec 18, 2013·Infection and Immunity·Maria Carolina FerreiraSarah L Gaffen
Jan 21, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna R HupplerSarah L Gaffen
Mar 13, 2014·Biological Procedures Online·Pushpa PandiyanAaron Weinberg
Apr 5, 2014·Current Protocols in Immunology·Heather R ContiSarah L Gaffen
Aug 2, 2014·Cytokine & Growth Factor Reviews·Annie M Bruns, Curt M Horvath
Aug 26, 2014·Nature Reviews. Immunology·Sarah L GaffenDaniel J Cua
Sep 10, 2014·The Journal of Experimental Medicine·Heather R ContiSarah L Gaffen
Jan 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey TomalkaAmy G Hise

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Citations

Jan 16, 2017·Cytokine·Michelle R Simpson-AbelsonMandy J McGeachy

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Methods Mentioned

BETA
PCR
biopsies
periodic acid Schiff

Software Mentioned

Graphpad Prism

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